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CRISPR-Cas9

⁨159⁩ ⁨likes⁩

Submitted ⁨⁨11⁩ ⁨hours⁩ ago⁩ by ⁨fossilesque@mander.xyz⁩ to ⁨science_memes@mander.xyz⁩

https://mander.xyz/pictrs/image/828cea5b-a9c4-4b83-846c-c98e17ddc5e7.jpeg

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Comments

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  • Contramuffin@lemmy.world ⁨10⁩ ⁨hours⁩ ago

    Explanation: CRISPR-Cas9 is most commonly known to be a gene editor, but since its initial discovery, people have found that with some minor tweaks, CRISPR can be made to do a bunch of other things, things that biologists could have only dreamed of previously.

    If you introduce a mutation that deactivates the Cas9 protein, the entire CRISPR complex still binds to DNA. Then, you can essentially glue whatever you want onto this modified Cas9 to produce a bunch of different effects:

    • deactivated Cas9, no additional modifications: blocks other proteins from touching the DNA, which suppresses a gene without destroying it
    • glue on some transcriptional activators: makes the cell express a gene
    • glue on some fluorescent proteins: makes your DNA glow, lets you see where it is
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    • ChillCapybara@discuss.tchncs.de ⁨6⁩ ⁨hours⁩ ago

      Well done! I zoomed in and felt dumb. But thanks to your succinct explanation, I now have a sweet Dunning-Kruger high

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  • DeltaWingDragon@sh.itjust.works ⁨10⁩ ⁨hours⁩ ago

    Genetic engineering has never been this cute

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    • riskable@programming.dev ⁨7⁩ ⁨hours⁩ ago

      I dunno. For hundreds of thousands of years we’ve been selectively breeding puppies.

      Puppies

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      • general_kitten@sopuli.xyz ⁨4⁩ ⁨hours⁩ ago

        In a way one could argue genetic engineering is one of the oldest sciences ever. And it started with dogs, or maybe agriculture, depends on what one’s definition of science is.

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  • BootyEnthusiast@lemmy.dbzer0.com ⁨10⁩ ⁨hours⁩ ago

    I want to >!fuck!< CRISPRi

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    • DeltaWingDragon@sh.itjust.works ⁨10⁩ ⁨hours⁩ ago

      Your spoiler failed

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      • Little8Lost@lemmy.world ⁨9⁩ ⁨minutes⁩ ago

        Sadly there are two spoiler types i know of :/
        for me the spoiler works because i use the “second one?”

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      • riskable@programming.dev ⁨7⁩ ⁨hours⁩ ago

        Your spoiler transcription suppressor failed

        FTFY 👍

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    • ZILtoid1991@lemmy.world ⁨4⁩ ⁨hours⁩ ago

      I prefer meowscarada.

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    • call_me_xale@lemmy.zip ⁨9⁩ ⁨hours⁩ ago

      “Did you know…”

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      • general_kitten@sopuli.xyz ⁨4⁩ ⁨hours⁩ ago

        “…that in terms of male human and female CRISPR-Cas9 variant reproduction, CRISPRi is the most compatible CRISPR-Cas9 variant for humans? Not only are they in the genetic perturbation group which is mostly comprised of various methods, CRISPRi are an average of…”

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