CRISPR-Cas9

Comments

• Contramuffin@lemmy.world ⁨3⁩ ⁨weeks⁩ ago

  Explanation: CRISPR-Cas9 is most commonly known to be a gene editor, but since its initial discovery, people have found that with some minor tweaks, CRISPR can be made to do a bunch of other things, things that biologists could have only dreamed of previously.

  If you introduce a mutation that deactivates the Cas9 protein, the entire CRISPR complex still binds to DNA. Then, you can essentially glue whatever you want onto this modified Cas9 to produce a bunch of different effects:

  • deactivated Cas9, no additional modifications: blocks other proteins from touching the DNA, which suppresses a gene without destroying it
  • glue on some transcriptional activators: makes the cell express a gene
  • glue on some fluorescent proteins: makes your DNA glow, lets you see where it is

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  • ChillCapybara@discuss.tchncs.de ⁨3⁩ ⁨weeks⁩ ago

    Well done! I zoomed in and felt dumb. But thanks to your succinct explanation, I now have a sweet Dunning-Kruger high

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• DeltaWingDragon@sh.itjust.works ⁨3⁩ ⁨weeks⁩ ago

  Genetic engineering has never been this cute

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  • riskable@programming.dev ⁨3⁩ ⁨weeks⁩ ago

    I dunno. For hundreds of thousands of years we’ve been selectively breeding puppies.

    Puppies

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    • general_kitten@sopuli.xyz ⁨3⁩ ⁨weeks⁩ ago

      In a way one could argue genetic engineering is one of the oldest sciences ever. And it started with dogs, or maybe agriculture, depends on what one’s definition of science is.

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    • emergencyfood@sh.itjust.works ⁨2⁩ ⁨weeks⁩ ago

      Whatever we did to pugs is definitely not cute. Or okay.

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• BootyEnthusiast@lemmy.dbzer0.com ⁨3⁩ ⁨weeks⁩ ago

  I want to >!fuck!< CRISPRi

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  • DeltaWingDragon@sh.itjust.works ⁨3⁩ ⁨weeks⁩ ago

    Your spoiler failed

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    • riskable@programming.dev ⁨3⁩ ⁨weeks⁩ ago

      Your spoiler transcription suppressor failed

      FTFY 👍

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    • Little8Lost@lemmy.world ⁨3⁩ ⁨weeks⁩ ago

      Sadly there are two spoiler types i know of :/
      for me the spoiler works because i use the “second one?”

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  • call_me_xale@lemmy.zip ⁨3⁩ ⁨weeks⁩ ago

    “Did you know…”

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    • general_kitten@sopuli.xyz ⁨3⁩ ⁨weeks⁩ ago

      “…that in terms of male human and female CRISPR-Cas9 variant reproduction, CRISPRi is the most compatible CRISPR-Cas9 variant for humans? Not only are they in the genetic perturbation group which is mostly comprised of various methods, CRISPRi are an average of…”

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  • xx3rawr@sh.itjust.works ⁨3⁩ ⁨weeks⁩ ago

    Can’t help it, it’s most compatible

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  • ZILtoid1991@lemmy.world ⁨3⁩ ⁨weeks⁩ ago

    I prefer meowscarada.

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    • joenforcer@midwest.social ⁨3⁩ ⁨weeks⁩ ago

      Y’all need Jesus. And an assigned FBI agent.

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