Contramuffin

@Contramuffin@lemmy.world

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  Submitted ⁨⁨4⁩ ⁨days⁩ ago⁩ to ⁨science_memes@mander.xyz⁩ | ⁨5⁩ ⁨comments⁩
• ⁨Comment⁩ on ⁨PLEASE bro⁩ ⁨⁨4⁩ ⁨days⁩ ago⁩:

  This is a map of signaling pathways in a cell. Essentially, how does a cell detect a stimulus and how does the cell respond to it. Signaling networks are notoriously difficult to parse, in major part because many of the proteins that make up the network are promiscuous (meaning that they target many types of proteins instead of just 1). Think of network as less of a series of defined steps and more of a chaotic mess. It’s so chaotic that most maps will select a theme (ie, hormone detection, stress signaling, infection, etc.) and only show the interactions that are relevant to that theme. Unfortunately, that also means that each map will show a network that’s completely different from the others, even though the proteins are the same.

  The joke here is that it’s very tempting to make another map. This map is finally going to solve cell biology, I promise, we just have to make another map. Ignore the fact that we already have so many maps, just one more map is all we need

• ⁨Comment⁩ on ⁨I'm a console gamer so, Why the hate on the Epic Games Store?⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  It was a while ago, I don’t remember off the top of my head which specific game I’m remembering. Doing a brief search, it appears that this happened to Unreal Tournament and Rocket League, though it appears that the games still work for the people who bought it before the unlisting. I think the concern was losing functionality, especially for server-based or multiplayer games

• ⁨Comment⁩ on ⁨I'm a console gamer so, Why the hate on the Epic Games Store?⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  Sweeney (the CEO of Epic) says that he wants competition with Steam, but many of his actions point toward that he really just wants to be the guy at the top (ie, he wants to be the monopoly instead of Valve). He’s taken a fair number of anti-consumerist stances, which vary from understandable to clearly anti-competitive.

  Epic is known for making exclusivity deals with 3rd party studios in which Epic bribes the studio with money, and in exchange, the studio does not release their game on Steam for 1 year.

  At several points, this occurred after a studio already said that they will release on Steam, and the studio would have to walk back and delete their Steam listing.

  Iirc, at one point Epic bought out a studio and had them remove the Steam listing for an already-released game, causing the game to be unplayable for people who had already bought the game

  The Epic Game Store released in a non-functional state, and development on it is extremely slow. The first impression of the broken store likely still influences many people’s impression of the store. But it’s still missing many features that many gamers want to see in a store.

  There were various rumors when the store first launched that it contained spyware. My understanding is that those rumors never fully got disproven, especially since some of the claims were supported by at least some evidence

  Epic does not support Linux, and Sweeney has openly said that he does not plan to support Linux until it becomes more popular. He did immediately jump on board with supporting Arm though, which caused a lot of Linux gamers to think that he just doesn’t want to support Linux

  Sweeney is a pretty abrasive person and iirc he made a lot of concerning statements on his social media. Several of them (as mentioned above) indicate that he wants to dethrone Valve so that he can be the monopoly instead

  Overall, many gamers are in support of more competition in the game store space. Unfortunately, many gamers also think that Epic is an untrustworthy competitor, and they believe that Epic has a serious chance of making the gaming industry worse if they become more popular. As a result, many would prefer for Steam remain the monopoly rather than to take a bet on Epic.

• ⁨Comment⁩ on ⁨Partner has ADD, do I have misophonia?⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  I don’t think you seem to have any problems, but it sounds like you’re partner may have some things that they’ll need to work out.

  People are creatures of habit - while it is true that your partner is being an asshole, I currently don’t have any reason to believe that they’re doing it out of malice rather than habit.

  It sounds like your partner may need to seek professional help, because it is their responsibility to manage their ADD/depression, and it sounds like they may be struggling to do that. It is not your responsibility to manage it for them

• ⁨Comment⁩ on ⁨if pure water is not conductive why would condensation be an issue for electronics?⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  Because it is really, really difficult to get pure water. Even distilled water isn’t pure. I’m not even sure you can get pure water outside of an industrial or laboratory setting

• ⁨Comment⁩ on ⁨It's My Nature⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  Reference to an Aesop fable. In the original version, the scorpion stings the frog and both of them drown. The moral is that some people are intrinsically harmful, even against their own self interest

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨3⁩ ⁨weeks⁩ ago⁩:

  I find that high school really doesn’t expose you to many of the most interesting fields and careers out there, and the subjects that it does expose to you are typically taught at a very basic, foundational level. To put it simply, I strongly believe that you and many other people in your situation don’t know what they’re passionate about because they don’t even know it exists.

  I think it’s the fault of the school system for not working harder to show the intricacies of actual careers, but for now, we just have to deal with what we’re given.

  We can try guessing what sorts of things you may like if you tell us a bit more about yourself. What sorts of things are you passionate about (ie, hobbies, obsessions, interests, favorite subject in school), and why do you feel passionate about it?

• ⁨Comment⁩ on ⁨Linux help and actual pros and cons⁩ ⁨⁨4⁩ ⁨weeks⁩ ago⁩:

  The distro itself doesn’t particularly matter. Unless you’re picking a niche distro or one designed for experts, all of them will have a good level of polish. What does matter is the desktop environment, which is the look and feel of the OS.

  Many distros offer various desktop environments, and it can be a good idea to take a look at different desktop environments and see which one you like. I personally enjoy KDE Plasma, since I feel like it resembles Windows 10 the most. A bunch of popular distros like Bazzite and Fedora offer KDE Plasma variants. Alternatively, many people also like Cinnamon, though I personally think it looks somewhat outdated. Cinnamon is primarily offered by Linux Mint.

  With the right desktop environment, Linux isn’t actually particularly technical. There’s definitely been a push recently to try to make things more user friendly. From time to time, you might still have to open terminal to do more advanced things, but I find that you can generally get by.

  However, the way you do things in Linux is pretty different than in Windows, and it definitely takes a bit of getting used to and building up a new set of muscle memory. You will get frustrated that something isn’t where you think it is. My advice is that you should dual boot and keep a copy of Windows, so that you can switch back to Windows when you just need to get stuff done.

  As for gaming, basically everything just works out of the box. I don’t even bother to check for Linux compatibility. Make sure to enable compatibility in the Steam settings and you should be good to go. The only time when games don’t work is if a game uses an anticheat that specifically blocks Linux - if you plan to play online games, it might be worth checking if the anticheat that it uses allows Linux or not. I haven’t tried modding so I can’t comment too much about that

• ⁨Comment⁩ on ⁨mmmm proper mammilian⁩ ⁨⁨4⁩ ⁨weeks⁩ ago⁩:

  Mmmm, no, very mammalian

• ⁨Comment⁩ on ⁨Anon uses Windows⁩ ⁨⁨4⁩ ⁨weeks⁩ ago⁩:

  Ironically, windows games run better on Linux than Linux games run on Linux. I wouldn’t worry about it, Proton (the thing that lets you run Windows games) is extremely good now. Just make sure to enable it in your Steam settings

• ⁨Comment⁩ on ⁨How long does it take for someone to reach a high level of drawing?⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  Depends on how much you like drawing. If it’s something fun for you, then it’s not time wasted and it’s definitely worth the effort.

  I will say that while constant practice is definitely important, it’s also important to have structured practice. Practice without structure will just lock in bad habits.

  By far the fastest and easiest way to improve quickly is to practice blocking. This is a technique where you simplify an object or a scene into simple geometric shapes - cubes, spheres, rectangles, etc. You draw out those shapes onto the page. Then, you add in the details. This forces you to map out where the objects are in your composition before you start drawing. Not only does it help with spatial awareness, it also lets you notice if the positioning of objects doesn’t look quite right and requires fixing, before you’ve spent a lot of time on drawing that object

• ⁨Comment⁩ on ⁨in case of emergencies, light it.⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  Ok but that one at least has a reasonable explanation. The temp control on the edges aren’t as good as in the center, so it’s more prone to messing up.

  Have you ever tried using a qPCR machine? That shit is actual black magic and you just have to hope that the spirits are feeling merciful that day

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  I’m on board with spending federal funds on crypto. Cryptosporidium parvum that is

• ⁨Comment⁩ on ⁨Clothes company cannot "cancel" an order that hasn't shipped, must ship it and do a return.⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  Technical debt applies not just to coding! (though it’s most often talked about in that context) It’s the general idea that whenever you rush a project by taking shortcuts, you have to spend more time later to sort it out (and let’s be honest, it’s never actually going to get sorted out)

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  Perhaps not necessarily wrong, but people sometimes don’t like hearing the truth. I don’t agree with the other comments that you should support him - to me, that sounds like bad parenting to not at minimum set up a backup plan when things start to fall apart.

  My take on this situation is that you may have to tell him in a more subtle manner. Fortunately, professional athletes are known for being notoriously competitive, where even talented people can lose out on an opportunity simply out of bad luck. This could give you a way to voice your concerns in a way that doesn’t directly imply that he’s not cut out for the job, ie “you still need to be very lucky to go pro. I was very fortunate, but we shouldn’t be counting on luck for your living. You can still try for it, but I really think you should also have some backup options if things don’t work out”

• ⁨Comment⁩ on ⁨Protein printer⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  On the flip side:

  nooo you can’t just wash your hands I have to spread to other hosts otherwise I’ll die

  haha water goes brrr

• ⁨Comment⁩ on ⁨Caption this.⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  A Russian peasant peeps through a hole in his walls and sees a coin, before transforming into a beast

• ⁨Comment⁩ on ⁨Unstable⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  In organic chemistry, there’s a concept called delocalized pi orbitals. The exact reason why it works is complicated and outside the scope of organic chemistry, so I’m not sure if I can really explain it anyways. But the takeaway is that when you see a double bond, single bond, double bond pattern, that generally indicates that the bonds are actually being shared across the entire motif. ie, it’s not really a double bond, it’s more like… a 1.5-bond.

  Having the bonds be shared across multiple atoms gives that region of the molecule special properties, the primary of which is that it tends to be really stable. The reason for that is that any disruption toward that region (eg, adding an electron) gets distributed across the motif, so that each atom is only minorly disturbed.

  And the bigger the motif is, the more stable the region is because it’s able to distribute disturbances better.

  Benzene (the hexagon motif circled) is made exclusively of this double bond, single bond, double bond motif. And as a result, it’s well known for being extremely difficult to modify or destroy. You really have to jump through hoops to do any sort of organic chemistry with benzenes. The motif circled in testosterone still has delocalized pi orbitals, but it’s not as extensive as a benzene, and so it’s less stable

• ⁨Comment⁩ on ⁨testtomcels⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  To summarize: paper got published last year that had this as a figure. It got widely ridiculed because there’s no way that this figure passed peer review. Turns out the reviewers did point it out but the editor ignored it

• ⁨Comment⁩ on ⁨get good, little kitty⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  It’s very simple:

  1. Learn about primer design
  2. Forget primer design
  3. Use a primer designer online
  4. ???
  5. Profit Primer fails
  6. Cry
• ⁨Comment⁩ on ⁨Acetone: A Thread⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Acetone evaporates quickly. You just let it sit for a minute and it’ll dispose of itself

• ⁨Comment⁩ on ⁨Why is Jury Nullification a Thing, But You Can’t Talk About It in Court?⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  So I can pitch in here. I was a juror on a trial where jury nullification was talked about. Multiple potential jurors did bring up jury nullification and the final jury contained some members who openly stated that they believed in jury nullification.

  The judge and the prosector actually didn’t really care that much - the judge just asked the juror something along the lines of “ok, but do you think you can stay impartial for this trial?”, and if the juror said yes, they were on the jury. And the prosecutor didn’t dismiss anyone.

  My understanding is that both the prosecutor and the defense get 10 freebie dismissals - they can dismiss up to 10 potential jurors for any reason. If the prosecutor wants to maximize the chances of getting a guilty verdict, they may potentially try to use those freebie dismissals to get rid of jurors who know about jury nullification. But it seems like, at least in my case, knowing about it (or even openly stating that you believe in it) doesn’t automatically disqualify you.

  The defense started talking jury nullification halfway through the trial (it was a wild trial), and that was where the judge drew the line. His reasoning was that the it was the judge’s role to instruct the jury on their job and role, so the defense cannot instruct the jury on their own about what to do. So it seems like you can talk about jury nullification, just not if you’re the defendant.

  As for why jury nullification isn’t commonplace, the prosecutor will try to convince the jury that the defendant deserves punishment. It doesn’t matter if you believe in jury nullification if you also believe that the defendant deserves to be in jail. If the prosecutor doesn’t make a convincing argument, then you’d just vote innocent and that’s not really jury nullification. So there’s really quite a long criteria for jury nullification to occur:

  1. The jury knows about and believes in jury nullification
  2. The jury disagrees with a particular law or case but also isn’t emotionally charged enough about it so as to remain impartial
  3. The jury believes that the law was broken, but is also unconvinced that the defendant deserves punishment
• ⁨Comment⁩ on ⁨For every 30 minutes theres a 50% chance my right shoe lace will come undone⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Left over right, then right over left. This creates a proper shoelace knot (aka double slipped square knot). You need to alternate. The alternation creates a self-tightening knot. If you do left over left, left over left (or the other way), then you’ve just done a granny knot, which will fall apart

• ⁨Comment⁩ on ⁨would getting back with an ex be a bad idea?⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Change isn’t necessarily impossible, but it’s really difficult and requires a huge amount of self discipline - if someone changes, they will be a standout exception rather then the norm. I urge you to consider that someone who ghosts you likely does not value you enough to be willing or able to put in the effort to change. Ghosting is deeply rude to do to anyone, and especially toward your significant other.

  Take my interpretation with a mountain of salt, because I don’t know the full story. But, from what you said, it seems more likely that he reached out to you because you were a convenient backup

• ⁨Comment⁩ on ⁨Further study is needed⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Your body is made of proteins. In the broadest sense, there are structural proteins and proteins that make important things. Some of the proteins that make things (called enzymes) require additional special molecules in order to function properly. These special molecules are called vitamins. Our bodies can make several vitamins but can’t make several other ones. The ones we can’t make has to be eaten, otherwise the enzyme won’t be able to function properly, and depending on what the enzyme does, you’ll either get sick or die or both. Vitamin C has to be eaten. Vitamin D, our bodies can produce. But the process to make it requires sunlight in order to function.

  TL;DR: our bodies have evolved to force you to touch grass

• ⁨Comment⁩ on ⁨Anon wants to watch an anime⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  I don’t personally think Anon knew exactly what he was trying to prove (otherwise he would have published the proof already), but it is definitely true that the problem was posted on a forum that specifically catered to people with the kinds of skillsets that would be capable of solving these problems. Most likely Anon probably just saw this as a simple math challenge without any deeper meaning

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Does me having autism increase your chances of finding a significant other?

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  What?

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  1. Not really, no. Love and attraction are different things. You don’t need to be attracted to someone you love.

  2. Unless you find your partner unattractive, I don’t see how sex could meaningfully change

  3. People are good at picking up social cues. That’s probably what you’re referring to. Humans are social creatures, after all. Also, people are trash at picking up social cues, so you’re probably also missing a lot of cues.

  4. That sounds like a really bad idea. Your sense of how common those relationships issues occur is warped. People don’t generally go into relationships trying to exploit someone. You’re going to cause issues (moral, logistical, and practical) with your plan, all because of a concern that’s not likely to happen.

  5. That’s the vast majority of humans. We are a monogamous species, after all. When you see “alpha males” on the internet, just be aware that they’re grifters that want your money. And the best way to make sure you keep giving them money is to make sure that you stay single and unhappy.

  6. Can’t help you there. I can at least tell you that enacting your plan in question 4 is going to lower your chances of finding a wife to 0.