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Comment on Would eating raw human brains make you high?

no your stomach acid would denature most of the proteins, then they’d be conjugated at the liver so whatever goes in will be transformed by what comes out. A lot of those hormones are tightly regulated so I’m thinking even if they make it into circulation they’d be eliminated fairly quickly. Only exception would be if they’re acid stable, not impacted on their way through the gut/metabolised by microbiota, absorbed in tact and still active after the first pass effect. Also theres enzymes like trypsin in your stomach that are specifically for degrading proteins so I doubt it would make you anything other than a canibal.

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Sethayy@sh.itjust.works ⁨8⁩ ⁨months⁩ ago
Would smoking raw human brains make you high?

Wait no thermal degredation

Would nebulizing raw human brains make you high? Especially of I got a little brain-diffuser in the corner that just filled the room with the aroma

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- JTskulk@lemmy.world ⁨8⁩ ⁨months⁩ ago
  Get me some brains and I’ll let you know.
  
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Nurse_Robot@lemmy.world ⁨8⁩ ⁨months⁩ ago
Okay, hear me out. Rectal route?

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- KingJalopy@lemm.ee ⁨8⁩ ⁨months⁩ ago
  Boofing brain
  
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  - fsxylo@sh.itjust.works ⁨8⁩ ⁨months⁩ ago
    And I’m done. No beating this today.
    
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    Mediocre_Bard@lemmy.world ⁨8⁩ ⁨months⁩ ago
    Coward. I’ll beat to this.
    
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  - PrincessLeiasCat@sh.itjust.works ⁨8⁩ ⁨months⁩ ago
    Boofing 2: Brain Boogaloo
    
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- medgremlin@lemmy.sdf.org ⁨8⁩ ⁨months⁩ ago
  It would still go through the liver for metabolism. The only thing “boofing” effectively does is skip the stomach part of the digestive process. To take up anything from the digestive tract, it gets transported through the intestinal lumen and into the mesenteric and hepatic portal system. The liver filters everything that gets into the blood from the gut before it goes into the inferior vena cava and into the rest of the circulatory system.
  
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  - Nurse_Robot@lemmy.world ⁨8⁩ ⁨months⁩ ago
    I don’t think that’s correct.
    
    Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation
    
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    medgremlin@lemmy.sdf.org ⁨8⁩ ⁨months⁩ ago
    The lower colon really only transports water and a couple of vitamins released by gut biota, so if they’re getting far enough in that more complex molecules would be taken up, that would probably be up into the hepatic portal system.
    
    The reason “boofing” works for alcohol is because ethanol is actually a rather small molecule, all things considered.
    
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TimewornTraveler@lemm.ee ⁨8⁩ ⁨months⁩ ago
conjugated???

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- Kyle_The_G@lemmy.world ⁨8⁩ ⁨months⁩ ago
  The liver “conjugates”/metabolises a bunch of stuff, its been almost a decade since I studied this stuff but bassically it will remove or add functional groups on/off a given compound. Most of what you eat heads straight to the liver for “processing” where food (and orally administered drugs) get altered prior to circulation. Its part of the first pass effect.
  
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set_secret@lemmy.world ⁨8⁩ ⁨months⁩ ago
you’re mostly right, however trypsin is produced in the pancreas and excreted into the duodenum, so not in the stomach. I think maybe you’re thinking of pepsin?

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- Kyle_The_G@lemmy.world ⁨8⁩ ⁨months⁩ ago
  Ya it was the first one to pop into my head as an example, the main point is anything active would be neutralized one way or another by the time it ended up in circulation.
  
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  - set_secret@lemmy.world ⁨8⁩ ⁨months⁩ ago
    yeah i agree.
    
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Scubus@sh.itjust.works ⁨8⁩ ⁨months⁩ ago
…so how many brains would i have to inject to get high?

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