daannii
@daannii@lemmy.world
- Comment on I will not stand for this information warfare any longer! 1 day ago:
Some speculate urine. Maybe pig urine. Which. Would show the ignorance of the Muslim faith by the guy.
But also. If urine. …
so Omar is a mother of 3. You think she hasn’t been urinated on?
I’m an aunt and all 3 of my nieces have leaked urine on me at some point while they were in diapers. It happens. It’s not that big of a deal. Washes off.
If it was urine, it wasn’t the offensive horrifying play this man might have thought it would be.
Let’s just be relieved it wasn’t something deadly.
- Comment on PISS 1 day ago:
Petrol!? PETROL!? DO NOT and I can’t emphasize this enough, DO NOT PUT GASOLINE IN A MOLOTOV COCKTAIL.
what will happen. It will explore the second you flick your lighter. Before it even comes into contact with the rag.
Gasoline is literally explosive. It’s not just an accelerant.
It will explode. The fumes are enough to make it explode.
- Comment on Tacos for dinner 2 days ago:
Didn’t marry him. Tried to find him on fb just now. Didn’t find him. Damn, hope he didn’t die of starvation or food poisoning.
I should have intervened more when I realized how unprepared he was for adulthood.
- Comment on Tacos for dinner 3 days ago:
Dear Mexicans, Europe needs you and your culinary skills so bad. Forget the U.S, get your ass to Greece !
- Comment on Now, which stop shall we go first ? 4 days ago:
The hump seat between the bucket seats will fit someone.
Won’t be comfortable. But you can squeeze someone in.
- Comment on Tacos for dinner 4 days ago:
This one time , in my mid 20s. I was dating this guy. He invited me over. Said he was going to make me nachos. He said he had a whole fancy way to make them. Really talked them up.
I get there and he puts chips on a plate. Covers in cooked ground hamburger and yellow cheese. Microwaves it.
(That was all the ingredients) And presented it to me like it was his best.
I mean maybe it was.
I personally don’t like that nasty yellow nacho cheese.
But I ate it anyway and complimented him.
But I was super disappointed. I still remember the event. 25 years ago.
Also I felt bad for him that he apparently didn’t know how to cook. He was like 27 then.
This image somehow brought up all those feelings of disappointment after all the hype and then followed by pity for the creator.
- Comment on Thanks 🙏🏻 5 days ago:
Yeah that’s actually the answer. I just wanted to see what other people suggested.
- Comment on Exploding 🌳🌲🌴🌳🌲🌴🌳🌲🌴🌳 6 days ago:
I always worry about the animals when we get these crazy cold times. How many die. It’s sad to think about.
- Comment on Thanks 🙏🏻 6 days ago:
I know the best way to get cat hair off things is
- Submitted 6 days ago to [deleted] | 2 comments
- Comment on The holy journey 6 days ago:
I repeatedly clarify the definition.
Have any luck finding peer reviewed papers with erowid references. ?
Maybe it’s cause it’s not a scientific resource.
- Comment on The holy journey 6 days ago:
That’s literally what I said
- Comment on The holy journey 1 week ago:
Because erowid does not meet the definition of a resource.
Again.
Links to resources is not itself a scientific resource.
I defined for you multiple times what “scientific resource” means.
Unlike erowid, maps actually conducted scientific research.
That’s why they are listed as a resource.
Even Wikipedia has people review the material.
Erowid does not.
You are uninformed about what science is. You refuse to acknowledge my definition. You know literally nothing about my research capabilities. Maybe I’m terrible at research but you wouldnt know one way or the other.
Which makes your opinion uninformed and therefore irrelevant.
Erowid are opinions of people who use recreational drugs. It’s not written by scientist. Or researchers. And research can be misunderstood by lay people.
As I said. Some of the information may be accurate. Doesn’t matter. It’s still not a scientific resource.
I, as a scientist, would not tell people to use lemmy or reddit to learn about neuroscience. I definitely wouldn’t advise using erowid for the same reasons.
Citing a resource does not make the text a resource.
- Comment on The holy journey 1 week ago:
What exactly is your point ?
First you say I’m not a “real” researcher because I didn’t give erowid as a resource.
I said it’s not scientific. You say “uh yeah it is”. I explain why it’s not and what “scientific” means because a lot of people are actually mis informed on this. And I didn’t want to argue semantics.
And then you say. That .
Are you also incapable of following your own arguments ?
What IS your argument then ?
- Comment on The holy journey 1 week ago:
Your links were irrelevant to your argument that erowid is a scientific resource.
It’s not.
- Comment on The holy journey 1 week ago:
The definition of a scientific resource is a RESOURCE with scientific observations and reporting that is peer reviewed or has some official review process like a university website with scholars writing the information that is verified by other scholars.
It’s the review process by people who are authorities on the topic that make that distinction. Scholars. Other scientist.
A comment on social media and anecdotal websites hosting forums is not a scientific resource. It’s opinions.
As I said earlier. Something doesn’t have to be scientifically validated to be true or real.
But it does have to be science to be science.
More specifically, experiments must use the scientific method and specific research statistic computations to support hypotheses which then are used to create theories.
Erowid does not have a review process where a senior scientist reviews any of the things posted on it.
Neither does Lemmy or faceb9ok,
Why is review so important?
Because humans are biased and our own subjective interpretation of patterns and events is not objective.
Just to illustrate some of the ways out thinking and interpretation of events is flawed, see cognitive biases on wikipedia.
And there are way more than these. en.wikipedia.org/wiki/List_of_cognitive_biases
And have a look at memory errors while you are at it. en.wikipedia.org/wiki/Memory_error
Oh and the best one. Bias blind sight. en.wikipedia.org/wiki/Bias_blind_spot
None of us, and I mean literally no one, is immune from these problems. Not me. Not you.
It’s why the only way we know anything for sure is through scientific methods of investigation. And even those aren’t full proof against bias.
I’m sorry that you don’t like the very basic explanation I gave of the properties of a drug you like. Some how that’s offensive to you.
I don’t know what to tell you.
I did get a few minor facts mixed up and i corrected them in the text. I Left in the original text and I crossed it out so that people could see I made a mistake and fixed it. Nothing I said was a huge big mistake about the drug. I misquoted the size of the tabs (10mm vs 5mm) and I was mistaken about it being neutralized in the stomach.
My gawd. Lock me up and send me a $500 fine. Jesus.
Maybe reflect on why it’s so important to you that your narrative of what the drug is, is being attacked from simple facts about how it works.
Why do you care how it works ? Why are you so invested in this? Why does it make you angry when someone explains the drug from a scientific perspective ?
If you don’t want to hear the scientific perspective then just ignore it.
It’s what a lot of people do.
- Comment on The holy journey 1 week ago:
Well literally anything can be addictive. People are addicted to gambling, to buying things online. To buying action figures or labubus.
But because lsd does not cause euphoria effects, it’s not typically considered chemically addictive. But there is not a complete consensus on this in the scientific field. Because it can still be behaviorally addictive. But as I said. Literally anything can be behaviorally addictive so that’s almost a moot point.
- Comment on The holy journey 1 week ago:
I specifically said I wasn’t sure about that story and asked if anyone else was familiar with it. I only gave two possible supports for an alternative explanation. However I also layer checked and clarified the specifics of stomach neutralization in an additional comment.
- Comment on The holy journey 1 week ago:
What would you call the structure of the lsd molecule that deposits on the paper?
Nothing I said about long term storage contradicts the specifics of the things that do break it down.
- Comment on The holy journey 1 week ago:
Erowid is not a scientific resource.
- Comment on The holy journey 1 week ago:
Erowid is personal opinions of drug users.
- Comment on The holy journey 1 week ago:
After re checking this information, I believe I was confusing DMT and LSD properties of not being active when ingested.
I remembered DMT can’t be ingested but I was sure it was true for LSD. But I was mistaken. LSD is neutralized by base not acids.
- Comment on The holy journey 1 week ago:
Novelty is a common effect that people don’t talk about much. Essentially it makes everything seem new and novel.
What’s interesting is, in the brain there is a specific spike in electrical activity (called event related potential, or ERP) that happens when you look at something new and unexpected. Some call it the novelty indicator. Designated P3a.
You can measure it with eeg equipment (electrodes on the scalp).
I’d be really interested to see if that ERP is happening more on LSD. It might shed more light on the mechanisms of the drug. If it doesn’t happen, then it would challenge the theory of what the P3a is.
I personally think LSD has a lot of potential to be used to research perception processing in the brain.Too bad it’s basically impossible to get approval to use it for that reason.
- Comment on The holy journey 1 week ago:
Ah yes you are correct. I definitely mis reported the size. It’s 5x5mm
- Comment on The holy journey 1 week ago:
Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.
That’s still different.
Even if the total quantity of the drug is small in the system once it gets there, it’s not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it’s original dose like most drugs/medicines.
You surely are aware of this ?
There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.
I’m not sure what you are talking about with dox trips.
Drugs like DMT /Ayahuasca also can’t be ingested unless they are mixed with a maoi inhibitor.
Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.
It’s possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don’t think there is research on this. But I’ll look into it.
But this idea that it’s not neutralized in the stomach is false. There is plenty of research on that.
- Comment on The holy journey 1 week ago:
Your stomach acid will definitely neutralize it. But after having it on your tongue for a while the drug has been deposited into your system.
- Comment on The holy journey 1 week ago:
You know there isn’t much in a single location aside from Wikipedia.
In textbooks I’ve come across , there is discussion of the pharmacology properties or a brief note about counter culture and general effects.
There is limited research on the drug as it’s been black listed for almost 50 years and even now, it’s primarily only researched for terminally ill people/mental health. Only a handful of those studies exist and none use double blind controls so the science quality is poor.
I myself am not convinced it has mental health benefits due to the way the drug works. It does however have strong suggestive effects meaning the drug itself promotes placebo/expectation effects.
The lecture I put together for my class (perception and sensation ) pulled info from a wide range of resources.
However there is one organization trying it’s best to do modern research and they have done some MRI studies. There was also a study on LSD and synesthesia which sheds a lot of light into the mechanisms. MAPS is the organization. maps.org
They have videos on YouTube with researchers discussing the research and studies they have done. But they mostly focus (last few years at least) on it’s use in mental health.
The drug property information I know about is mostly pulled from old research from the 60s before the research bans. A lot was done on animals to understand dosage and half life. The cascade effects of how this drug works are still not really understood. We do know that the drug is similar in structure to serotonin. But there are still a lot of unknowns.
Let me dig around for my resource links. I have a few interesting studies I found when preparing the lecture, including the synesthesia one, and I’ll organize it all and I’ll put a link up to a g drive with it.
The lecture I did was 3 hrs long about hallucinations with a chunk dedicated to psychedelics. It did rely on other lecture materials to understand or otherwise id just put it up. (It was the final lecture for the class so it referred back multiple times to previous lessons). But maybe I can re-write it a bit. I’ve honestly been thinking of turning it into a video for a while because there are so few resources out there that review it more broadly. And a hell of a lot of misinformation about hallucinations and psychedelics.
Basically this lecture was on hallucinations and the primary causes and how each of these causes relies on the same root changes in brain processing.
For instance. You are driving on a country road at night. Vigilant to look for deer. Multiple times you were sure you saw an animal near the road but soon realized it was a fence post. Or an old glass bottle reflecting your headlamps. But for a split moment you did see an animal there before you corrected the perception.
What ultimately caused that is what causes hallucinations in other situations. Like schizophrenia and drug use.
So we circle around neuroscience, psychiatry, physiology, and pharmacology. As well as cultural impacts influencing the experience of hallucinations or psychedelics.
This is getting long. Apologies. The lecture is 3 hrs and relies on many other hours of information. It’s a big topic.
- Comment on The holy journey 1 week ago:
I mean it depends on the person and the dose on the tabs. Like most recreational illegal drugs, it’s hard to know how much is actually present on the tabs.
Many times drugs are diluted at various steps of transport and selling. Though it is harder to do that to a drug already on paper like this.
- Comment on The holy journey 1 week ago:
Lsd is often distributed and consumed via small paper squares called blotter paper. The paper is thick like cardstock. Sometimes with colorful psychedelic artwork printed on it.
The lsd is diluted in a solution and the paper is soaked in the solution. Usually alcohol.
The tiny microscopic lsd crystals deposit on the paper. The blotter paper is divided into 1cm squares.
Lsd is neutralized by many chemicals , including chlorine (found in tap water) and stomach enzymes. It cannot be swallowed and still have an effect.
To take LSD, a person will place squares (typically one square is 1x 100ug dose) of the paper on the tounge or under it. And hold for about 15 minutes. Some people take more than one. It can’t kill you. But it can lead to accidents in high doses that can kill you. So it’s not risk free even if health risks are low.
Also I said ug. Not mg. The lsd drug is very unique in that it has high potency at micrograms. Fentanyl is another drug that has that property . But it is rare.
The lining of the mouth (mucus membranes) allows for easy transfer of the drug into the blood stream. That’s true for a lot of drugs actually.
This is why lsd has such a unique drug delivery method though. It can’t be swallowed and it should be used in very small doses.
Lsd is also very resistant to degeneration. Oxygen, sunlight, and neutralizing chemicals like chlorine can degrade it. But if it’s stored properly it can last a very very long time. This is another rare property it has.
It’s also clear, tasteless, and no odor.
I’m a perception researcher and , of course, this would be a drug on my radar. So I know quite a bit about it. I’ve given a lecture on psychedelics. It’s a fascinating topic.
Also I’m generally interested in psycho-pharmacology because , well, it’s interesting.
If you want to learn more interesting facts about LSD and other psychedelics, ask away.
- Submitted 1 week ago to [deleted] | 101 comments
