Drewsteau
@Drewsteau@lemmy.world
- Comment on Women in STEM 1 month ago:
Fuck Watson and Crick, all my homies hate Watson and Crick
- Comment on Women in STEM 1 month ago:
First thing I thought too!!
- Comment on There can be only one winner 1 month ago:
That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.
One major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.
All this being said, definitely never a reason to go above 5mg
- Comment on There can be only one winner 1 month ago:
Please do! Research has shown that as little as 20 minutes of light therapy in the morning can have positive effects
- Comment on There can be only one winner 1 month ago:
Hey, I commented elsewhere on this post and I wanted to let you know that the reason it doesn’t help you is likely because all melatonin supplements are way too strong!! Our body is releasing .3-.5mg of melatonin during the evening, and over the counter melatonin ranges from 5mg-20(!!)mg per pill.
As you can see, this is WAY too much for our body, and it saturates every melatonin receptor in the brain resulting in over signaling of these pathways and a tolerance to melatonin. People who consistently take it each night can really mess up the sleep related pathways in the brain, and the desensitization means that the naturally released melatonin is not even close to creating the proper response in the brain.
It can be difficult to find in some places, but if you’d like to use it there are 1mg supplements out there that I would recommend! :)
- Comment on There can be only one winner 1 month ago:
Absolutely! Additionally, morning sun is another great way to regulate your circadian clock and let your body start its internal timer for melatonin release.
In the winter, I use a light box for seasonal affective disorder, and in addition to feeling much more energized, I find it helps me get more consistent sleep!
- Comment on There can be only one winner 1 month ago:
You’re on the right track, but funnily enough you got it switched around!
Research shows that melatonin binding leads to downstream release of adenosine, so if caffeine is blocking its binding action sleep is not on the way!
Here’s the paper I am referencing: www.ncbi.nlm.nih.gov/pmc/articles/PMC4851458/#:~:….
“We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep”
- Comment on There can be only one winner 1 month ago:
That’s great! I really do think 1-1.5mg is the upper limit anyone should use, although it’s still higher than free melatonin concentration in your brain it’s a much more reasonable does in comparison.
And I think most people who don’t understand melatonin go straight for the 20mg, so we’re probably talking 60+.
It really blows my mind that in this day and age there are no regulations or at the very least warnings or guidelines regarding melatonin supplements.
- Comment on There can be only one winner 1 month ago:
0x0 is correct. If it’s a prescribe medication then my comment is not relevant! I am referring to over the counter supplements
- Comment on There can be only one winner 1 month ago:
FYI, every melatonin supplement is way too high of a dose and is completely saturating your melatonin receptors, leading to tolerance and dependency.
Your body is not producing more than .5mg of melatonin naturally, so taking a 5mg supplement far too much. And they sell 15-20mg too. If you can find 1mg that’s best; but what’s even better in the long run is not using it!
- Comment on Discussion Thread: Team USA vs Team Puerto Rico 1 year ago:
Someone cooked here
- Comment on [Woj] BREAKING: The Portland Trail Blazers are trading guard Damian Lillard to the Milwaukee Bucks, sources tell ESPN. 1 year ago:
That sure is a roster with a ton of potential
- Comment on [Woj] BREAKING: The Portland Trail Blazers are trading guard Damian Lillard to the Milwaukee Bucks, sources tell ESPN. 1 year ago:
Massive trade. Really sad to see Jrue leave, he was so good for the bucks. This means they will likely be relying even more heavily on Brook Lopez to anchor the defense. Also I know Phoenix wanted to get rid if Ayton but Nurk seems like a downgrade
- Comment on Update: Kevin Porter jr's Girlfriend has broken Vertebra in neck 1 year ago:
Absolute scum. He doesn’t deserve to be in the league and neither does any domestic abuser. Still can’t believe Miles Bridges and Jaxson Hayes are still there
- Comment on Kevin Porter Jr. arrested on assault 1 year ago:
Not just anyone, his girlfriend!
- Comment on Kevin Porter Jr. arrested on assault 1 year ago:
Really don’t like how they very intentionally make that headline sound like he got into a bar fight when he was actually domestically abusing his partner
- Comment on The US hasn't won a medal at two consecutive FIBA World Cups, this is the first time this has happened since they started sending pro players in 1994 1 year ago:
It’s kind of frustrating how the top US players in the league don’t seem interested at all in playing in the World Cup.
If we had Steph, KD, Dame, Tatum, Brown, AD, Lebron, Harden, etc it would be so exciting to watch. Everyone would be talking about them all off-season. I mean we can barely even convince some dudes to play in the Olympics, I just don’t get it. The load management excuse is so lame.
- Comment on Christian’s Wood has signed with the Los Angeles Lakers 1 year ago:
Waiting for the news to break they signed his legs too 🤞🏻
- Comment on Canada beats Slovenia 100-89 1 year ago:
So annoying. I think before last season Coach Kidd said he talked to him about easing up on talking to the refs, and that lasted about 2 games.
One of his only downsides as a player but it’s a big one. How many times did we see the mavs give up points on a 4v5 break because Luka was too busy whining to get back on defense? The excuse was that he’s young but he’s far enough into his career to mature out of this behavior.
- Comment on Germany beats Latvia in a close one 81-79 1 year ago:
Rematch incoming! Hopefully Coach Kerr and company will have a good game plan to deal with their size since he has one game of info to go on. Certainly helps our confidence that we won last time, granted it was close.
- Comment on Per sports illustrated Kawhi and PG are talking to Harden 1 year ago:
Agreed and I’m very skeptical the clippers have a trade package enticing enough for him to think that’s a worthwhile deal if they plan on retaining PG and Kawhi. Would be a skeleton roster lol
- Comment on why isn't the use of the bidet more widespread? 1 year ago:
Honestly I wouldn’t even be surprised if Procter and Gamble did that shit lol
- Comment on Canada's Murray withdraws from FIBA World Cup 1 year ago:
Definitely a huge bummer, I was really looking forward to watching team Canada as well. On the bright side, this will likely result in SGA getting more possessions as the primary ball handler which could result in some exciting performances from him!
- Comment on Harden sells 10,000 bottles of his wine in 10 seconds 1 year ago:
“It’s time to get uncomfortable” says James Harden as he sits back, uncorks a fresh bottle of his signature wine, pours himself a glass by the fire, and sells 10,000 bottles in 10 seconds
- Comment on Best basketball podcast right now? 1 year ago:
Understood. Bontemps and McMan can definitely be annoying sometimes lol but Windy always cracks me up
- Comment on Best basketball podcast right now? 1 year ago:
Do you listen to Hoop Collective? I love Windhorst. Lowe Post and HC are my 1/2
- Comment on USA vs SPAIN | FULL GAME HIGHLIGHTS 1 year ago:
Great game! Tough competition and a good litmus test for this team. Some of the calls throughout the game were pretty tough (like the defensive foul on JJJ that I thought was totally an offensive push by Hernangomez) and some ticky tack stuff. Only 5 fouls per player which is a big adjustment.
Definitely a noticeable difference in how FIBA is officiated. One of the worst parts for me was someone trying to get that cheesy pull up 3 foul that I knew no one would call, just looked so dumb lol.
Looking forward to see how this team does!
- Comment on [Shams] Free agent F/C Derrick Jones Jr. has agreed to a one-year fully guaranteed deal with the Dallas Mavericks, his agent Aaron Turner of @VerusTeam told @TheAthletic @Stadium. 1 year ago:
Good for him. It was painful to watch Billy Donovan play him as a small ball 5 in Chicago, he was totally misused
- Submitted 1 year ago to nba@lemmy.world | 3 comments
- Comment on 2024 NBA Mock Draft: The prospects you need to know next season 1 year ago:
Thanks but I’ll educate myself on next years draft class at the same time I always do, 30 minutes before my team is up to pick