That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.

One major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.

All this being said, definitely never a reason to go above 5mg