Comment on If you have diarrhea and you hold it in will your body retain some of the water?

• AAA@feddit.org ⁨1⁩ ⁨week⁩ ago

  That’s the

  your body thinks whatever is in your bowels is not safe

  part.

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  • dragonfucker@lemmy.nz ⁨1⁩ ⁨week⁩ ago

    Is there any way to increase the intestines’ spice tolerance?

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    • Kit@lemmy.blahaj.zone ⁨1⁩ ⁨week⁩ ago

      Exposure over time, slowly ramping up intensity.

      source
• EtherWhack@lemmy.world ⁨1⁩ ⁨week⁩ ago

  pmc.ncbi.nlm.nih.gov/articles/PMC8909049/ (2022 Feb 25)

  In summary, mice were intragastrically administered with CAP at three doses to evaluate the effects of CAP on GI health. The results showed that administration of 40 mg/kg CAP did not have significant negative effects on the GI tract in mice, while 60 and 80 mg/kg CAP caused GI injury by damaging GI tissues and decreasing the levels of anti-inflammatory cytokines (IL-10). Inflammation and histopathological changes were significant in the jejunum, ileum, and colon, but only slight in the stomach. CAP increased serum SP and CGRP levels in a dose-dependent manner, which may induce an immune response and visceral pain. The levels of cecal SCFAs also significantly changed in the 80 mg/kg CAP-treated groups. These effects of CAP might be related to the regulation of gut microbiota, especially Bifidobacterium, Lactobacillus, Faecalibacterium, and Butyricimonas. Moreover, the underlying mechanism of the correlation between serum neuropeptides and specific gut microbiota needs to be studied, suggesting that probiotics, as members of the gut microbiota, may be an alternative in relieving CAP-induced GI injury. These data will reveal the effects of CAP on GI health, provide insight into the experimental model of CAP-induced GI injury, and enrich the correlation analysis between CAP ingestion and gut microbiota.

  It looks like it’s still being studied. For now, I guess you can resolve it to being an irritant when ingested in larger quantities than your body likes.

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• Nollij@sopuli.xyz ⁨1⁩ ⁨week⁩ ago

  I can tell you that this is not universal. I eat very spicy food on a regular basis, and it does not give me diarrhea.

  I can’t remember a time that it did, either. I remember when I felt the burn, twice, but not from diarrhea. Is it possible that it’s not the spice, but the spicy food? For instance, is your body reacting to the greasy chicken wings instead of the capsaicin?

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  • adespoton@lemmy.ca ⁨1⁩ ⁨week⁩ ago

    Or for that matter, the salmonella on the chicken that’s being covered up with spices?

    I likewise have felt the burn but never had diarrhea from spicy food — just food that wasn’t fresh.

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