Comment on Larry and the Legend of the Ligand Key

abfarid@startrek.website ⁨2⁩ ⁨months⁩ ago

• AltheaHunter@lemmy.blahaj.zone ⁨2⁩ ⁨months⁩ ago

  The large purple rectangle is a protein channel across a cell membrane. It’s normally closed, but can be opened by binding to a specific small molecule, which is called a ligand. Different channels have different ligands, and their presence/absence controls whether the channels will open.

  In the cartoon Larry the ligand has been traveling with his friends, who represent the cargo to be transferred through that channel. When they reach the closed channel, Larry uses himself as the “key” to open the channel. Since channels usually only stay open while the ligand is still bound, Larry stays behind to keep the channel open while his friends make their way forward.

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  • stoicmaverick@lemmy.world ⁨2⁩ ⁨months⁩ ago

    I had the reverse problem, where I’m basically aware of all of the above, but I stared at it for like five straight minutes trying to figure out if there was a deeper joke relating to what the molecules were actually supposed to be, but I think I read too far into it.

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    • model_tar_gz@lemmy.world ⁨2⁩ ⁨months⁩ ago

      Did you watch or read The Fellowship of the Ring?

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      • stoicmaverick@lemmy.world ⁨2⁩ ⁨months⁩ ago

        Only the hentai adaptation. Why?

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  • abfarid@startrek.website ⁨2⁩ ⁨months⁩ ago

    Thank you very much!
    I assume that only Larry type molecules were supposed to enter the cell?

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    • AltheaHunter@lemmy.blahaj.zone ⁨2⁩ ⁨months⁩ ago

      No, Larry’s friends are supposed to enter, Larry is there to let them in.

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      • abfarid@startrek.website ⁨2⁩ ⁨months⁩ ago

        Again, thank you for the answer. And thank you for mimicking my rather useless emphasis.

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    • Cethin@lemmy.zip ⁨2⁩ ⁨months⁩ ago

      This isn’t my strong suit either, but I think no. They open the channel so that other things can go through. They themselves are only the key to let the rest through. The cell needs a lot of stuff to function but this keeps the junk out.

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• stelelor@lemmy.ca ⁨2⁩ ⁨months⁩ ago

  The joke would have worked a lot better if Larry’s friends were different shapes. There’s no visual reason why Larry is the only one that can act as the key.

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• abbadon420@lemm.ee ⁨2⁩ ⁨months⁩ ago

  It fits, it sits

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