appel
@appel@whiskers.bim.boats
Wants to be on a boat
- Comment on What are some good PSP games? 1 month ago:
Maybe try Phantasy Star Portable 2
- Comment on Let's discuss: LEGO Games 1 month ago:
Wow that’s amazing, thank you. It was the voa nui game I was thinking of. Is there something like this for the other Lego web games?
- Comment on Let's discuss: LEGO Games 1 month ago:
I played this open world Lego game where you had to deliver pizzas on a skateboard or something, but I was too young and couldn’t figure out how to complete the game, or it kept bugging. I can’t remember what it was called
- Comment on This Guy Has Built an Open Source Search Engine as an Alternative to Google in His Spare Time 2 months ago:
So have many others, except they didn’t start a company based on it. As soon as it is part of a company, it is no longer free and open
- Comment on Scientists generate first single-cell atlas of the primate brain 6 months ago:
I hope this provides some real benefit so those macaques didn’t give up their brains in vain :(
- Comment on Cell biologists identify new organelle present in mammalian cells made of rings of DNA 6 months ago:
Ah I see, so plasmids can be introduced by bacterial infections. I was wondering otherwise how would they end up in mammalian cells. Although it seems this structure is basically a dump for extra nuclear DNA, whether it’s self or other.
- Comment on Cell biologists identify new organelle present in mammalian cells made of rings of DNA 7 months ago:
Plasmids in eukaryotic cells?
- Comment on Gene regulatory network - Clock and Flip-flop 8 months ago:
This is pretty cool, but is there a reason to use NN rather than differential equations? Seems like it might be more computationally expensive.
Are you using some kind of declarative language to define the networks? Not sure if a standard for that exists yet. There are the standard symbols for genetic circuits though.
- Comment on Environmental protester halt the world championship in cycling... one of the best alternatives to fuel driven transportation.... 8 months ago:
I am indeed talking about consumer high-end cycling, and I see it poisoning peoples minds in my city with their marketing that says to be eco-friendly and cycle to work you have to buy a brand new bike for £1000. I am arguing about the case in my city and the direction I don’t want to see cycling in general take. I agree with you that in many places, cycling is much better, the Netherlands is a great example. I am not going after cycling as a whole, just the rich directors of Shimano, SRAM, Trek, Specialized, etc. that have greenwashed expensive high-end cycling and make people believe that they need the latest stuff. I am not saying that the industry is already in a bad place, just that it could head that way.
- Comment on Environmental protester halt the world championship in cycling... one of the best alternatives to fuel driven transportation.... 8 months ago:
I’m not arguing against a strawman, I’m arguing against an extreme case. In the city where I live, people buying loads of fancy new expensive bikes to seem “eco-friendly” is large. The number of high-end bike shops is large. Repair costs are extreme; £60 for a medium job. This is of course, a predominantly white, affluent city. I regularly see new gravel and commuter bikes (the latest trend) manufactured by the likes of Specialized, Trek, Canyon. These cost in the region of £1000 ± 200. I agree that there is not mass migration away from standard parts yet, but I am worried that that is the direction the cycling industry wants to take. There is already an explosion of different cassette standards, meaning you need unique tools to change many of the new cassettes. Disk brakes add complexity and expense, and your average commuter bike arguably does not need disk brakes, they are just a shiny addition to make it more marketable. My argument is against the increase of these expensive bikes, fancy parts and brands that produce them, as it just pushes people away from cycling and the ecological and health benefits it can bring.
- Comment on Environmental protester halt the world championship in cycling... one of the best alternatives to fuel driven transportation.... 8 months ago:
I don’t know the ideologies of the protestors, but I do agree with protesting against “big cycling”. Cycling around on a trusty steel bike which you can repair yourself is environmentally friendly. Buying a new carbon fiber bike every few years because it is 2% more aero than the last is not. Instead of standardized parts, the cycling industry wants you to buy cheap ones that break fast, and can only be replaced with their specific parts. They sell this to you by including some upgrades in chains, cassettes etc. The cycling industry is the same as any other industry, it exists to make profits. Truly sustainable things do not come from making profits.
- Comment on Turning plants into biological factories – Earth News | Particle 10 months ago:
Afaik, it depends on where the medicine came from, if it's from a eukaryote (compounds from plants, fungi, animals) then it may be glycosylated, and you'd therefore have to produce it in a host that supports glycosylation (another eukaryote). I think prokaryotes also have some features of transcription and translation that make them different to eukaryotes, but I can't remember off the top of my head.
But to be honest, I think the point of this may be that growing stuff in a plant is easier than using a bioreactor or flask.
For a plant, you need:
- Soil
- Water
- Light
- A bag of seeds
For a bioreactor you need:
- A bioreactor (not cheap)
- Sterilisation equipment
- Closed processing equipment (tubes, filters, tube welders)
- Bioreactor control device
- Biological safety cabinet to work in
- Sterile media, probably with specific additives depending on your cell line
- All of the numerous plastic consumables used in modern labs
- Liquid nitrogen storage of cells
- Probably some more stuff
Dunno about you, but the former sounds easier to do in a space station to me.