Comment on Turning plants into biological factories – Earth News | Particle
appel@whiskers.bim.boats 1 year agoAfaik, it depends on where the medicine came from, if it's from a eukaryote (compounds from plants, fungi, animals) then it may be glycosylated, and you'd therefore have to produce it in a host that supports glycosylation (another eukaryote). I think prokaryotes also have some features of transcription and translation that make them different to eukaryotes, but I can't remember off the top of my head.
But to be honest, I think the point of this may be that growing stuff in a plant is easier than using a bioreactor or flask.
For a plant, you need:
- Soil
- Water
- Light
- A bag of seeds
For a bioreactor you need:
- A bioreactor (not cheap)
- Sterilisation equipment
- Closed processing equipment (tubes, filters, tube welders)
- Bioreactor control device
- Biological safety cabinet to work in
- Sterile media, probably with specific additives depending on your cell line
- All of the numerous plastic consumables used in modern labs
- Liquid nitrogen storage of cells
- Probably some more stuff
Dunno about you, but the former sounds easier to do in a space station to me.
Sal@mander.xyz 1 year ago
Those are some great points, thank you! I wasn't aware (and if I ever was, I forgot!) that glycosylation was much more common in eukaryotes than in prokaryotes - that is very interesting.
Still, I think that the technical requirements for an extraction are much more accessible than an industrial a bioreactor setup. So your points still stand.
eporetsky@lemmy.world 1 year ago
Another point I can think of is that storing a bunch of seeds in tubes at room temperature for many decades is trivial compared to cryo-storing microbes. Might make it easier to handle if you decide to produce the genetically engineered plants on earth. Just collect a few seeds from each strain that produces a specific useful thing and germinate the seeds when you need it