CRISPR used to remove extra chromosomes in Down syndrome and restore cell function

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• Ledericas@lemm.ee ⁨23⁩ ⁨hours⁩ ago

  works while as the egg, but not as grown human.

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  • protist@mander.xyz ⁨20⁩ ⁨hours⁩ ago

    This is not true on multiple levels. One of the benefits of the Crispr technique is it can be used in vivo, so this sort of treatment will potentially be able to be used at any point in an individual’s life. But also, trisomy-21 isn’t present in sperm or eggs, it’s a mistake in cell division early in fetal development, so applying this technique to an egg would have no purpose or effect.

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    • dondelelcaro@lemmy.world ⁨16⁩ ⁨hours⁩ ago

      trisomy-21 isn’t present in sperm or eggs, it’s a mistake in cell division early in fetal development

      This is incorrect. Non-disjunction (where chromosomes incorrectly separate) typically happens during the formation of egg or sperm. (We know this because most everyone with down syndrome has three different chromosome 21 instead of two identical copies of one chromosome.)

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• RedSnt@feddit.dk ⁨1⁩ ⁨day⁩ ago

  This opens the door to so many possibilities. I’m just a dumb-dumb, but skimming through this: pmc.ncbi.nlm.nih.gov/articles/PMC7508700/ it seems that organ xenotransplantation might become a reality in the not too distant future.

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• FundMECFSResearch@lemmy.blahaj.zone ⁨22⁩ ⁨hours⁩ ago

  • In mice

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  • protist@mander.xyz ⁨20⁩ ⁨hours⁩ ago

    This research was conducted on four human induced pluripotent stem cell lines:

    In our previous work, we generated a trisomy 21 iPS cell line derived from skin fibroblasts and three induced disomy iPS cell lines with different combinations of HSA21 (ΔP, ΔM1, and ΔM2) using the chromosome elimination technique

    Here’s the previous work

    How did you even come to the conclusion mice were involved? Mice aren’t mentioned anywhere

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  • Breezy@lemmy.world ⁨20⁩ ⁨hours⁩ ago

    Well they’re not allowed to splice up human kid’s dna. If your child had something believed curable through this method would you sign them up for it?

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    • protist@mander.xyz ⁨20⁩ ⁨hours⁩ ago

      All this research was done on human cells in vitro. The person you’re responding to was making shit up

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• x00z@lemmy.world ⁨1⁩ ⁨day⁩ ago

  This is awesome news but I thought this news was already from a few months ago.

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