so grapefruit can either increase or decrease your metabolism rate of some drugs. It doesn’t just block it entirely.
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SnotFlickerman@lemmy.blahaj.zone 2 months agoSo the CBD thing really bugs me, in particular.
So one of my medications has one of those warnings about how you can’t have grapefruit while taking this medication. That’s because grapefruit is metabolized on a certain chemical pathway that gets interrupted. That pathway is CYP3A4.
You know what else takes that chemical pathway? Fucking CBD. It also blocks the chemical pathway, making any drugs administered less effective because they can’t bind to where they need to because the CBD molecule is already there.
So like, for me, these are life saving medications so fucking around with this is really stupid but literally no doctor told me this. I accidentally figured this out while doing research on CBD. It seems like its becoming more publicized now, but the bottom line is this:
If you have medication that warns you that you should not eat grapefruit with this medication (about 60% of medications, I believe), that medication needs the same warning about CBD.
HeyThisIsntTheYMCA@lemmy.world 2 months ago
deranger@sh.itjust.works 2 months ago
It only makes prodrugs that first need to be metabolized by CYP3A4 less effective. It makes drugs that are inactivated by CYP3A4 more effective, which is the majority. It also only competitively inhibits while the drug is in your system, it’s not permanently inhibiting the enzyme like a suicide inhibitor.