Comment on My cat just came home smelling like weed. What should I do?
Lemminary@lemmy.world 3 months agoAs much as I’d love to have my cats smoke with me, I think it’s toxic for them. Sadge. :(
Comment on My cat just came home smelling like weed. What should I do?
Lemminary@lemmy.world 3 months agoAs much as I’d love to have my cats smoke with me, I think it’s toxic for them. Sadge. :(
EleventhHour@lemmy.world 3 months ago
They’re all allergic?
Lemminary@lemmy.world 3 months ago
No, allergies happen when the immune system detects innocuous substances as a threat. In this case, their metabolism has trouble breaking down the drugs in their gut so it can have unintended consequences for them. They can’t metabolize some organic structures in their livers or lungs as fast or as much as we do. And unfortunately, we don’t even know what the toxic dose is.
EleventhHour@lemmy.world 3 months ago
Theoretically that’s possible, but what makes you think that cannabinoids would have that effect on a cat? What do you have of this?
Lemminary@lemmy.world 3 months ago
Yes, and that’s a bit of a wrong assumption because cats don’t have the same enzymes we do, and even if they did, their physiology doesn’t allow for the same quantity of expression. For example, if a cleaving enzyme is anchored to the lumen of your liver, lungs, or kidneys, the surface area of those tissues may not be enough to reduce the concentration in the blood, If they have an alternate gene that does the same thing, it’s usually less effective or it could produce prodrugs that may be more toxic than the original. Also, the bioavailability of drugs largely depends on the route of exposure which is very short for cats because they have a shorter respiratory tract and the blood volume is magnitudes smaller.
In short, couple the rate of exposure with the volume of blood and a lower rate of metabolism, and your cat can reach higher levels of the drug in the blood than you’d expect. You can’t rely on what is toxic to humans to translate to another species and vice-versa or we’d have a lot more productive studies on mice.
As for the evidence, I’m sorry but I’m gonna have to outsource that to Consensus via ChatGPT which usually does a good job finding relevant science articles because I’m not well-versed in the literature. I hope it doesn’t bother you but I don’t have the time or energy to do it myself right now.
Behavioral Changes:
Cardiovascular and Respiratory Effects:
Safety and Tolerability:
Veterinary Reports: