Comment on My cat just came home smelling like weed. What should I do?

• EleventhHour@lemmy.world ⁨1⁩ ⁨month⁩ ago

  They’re all allergic?

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  • Lemminary@lemmy.world ⁨1⁩ ⁨month⁩ ago

    No, allergies happen when the immune system detects innocuous substances as a threat. In this case, their metabolism has trouble breaking down the drugs in their gut so it can have unintended consequences for them. They can’t metabolize some organic structures in their livers or lungs as fast or as much as we do. And unfortunately, we don’t even know what the toxic dose is.

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    • EleventhHour@lemmy.world ⁨1⁩ ⁨month⁩ ago

      Theoretically that’s possible, but what makes you think that cannabinoids would have that effect on a cat? What do you have of this?

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      • Lemminary@lemmy.world ⁨1⁩ ⁨month⁩ ago

        One would think the same would apply for a cat.

        Yes, and that’s a bit of a wrong assumption because cats don’t have the same enzymes we do, and even if they did, their physiology doesn’t allow for the same quantity of expression. For example, if a cleaving enzyme is anchored to the lumen of your liver, lungs, or kidneys, the surface area of those tissues may not be enough to reduce the concentration in the blood, If they have an alternate gene that does the same thing, it’s usually less effective or it could produce prodrugs that may be more toxic than the original. Also, the bioavailability of drugs largely depends on the route of exposure which is very short for cats because they have a shorter respiratory tract and the blood volume is magnitudes smaller.

        In short, couple the rate of exposure with the volume of blood and a lower rate of metabolism, and your cat can reach higher levels of the drug in the blood than you’d expect. You can’t rely on what is toxic to humans to translate to another species and vice-versa or we’d have a lot more productive studies on mice.

        As for the evidence, I’m sorry but I’m gonna have to outsource that to Consensus via ChatGPT which usually does a good job finding relevant science articles because I’m not well-versed in the literature. I hope it doesn’t bother you but I don’t have the time or energy to do it myself right now.

        Behavioral Changes:

        A case of a 6-year-old Persian cat exposed to marijuana smoke showed severe agitation, aggression, and alternating states of apathy and agitation. Blood tests confirmed the presence of delta-9-tetrahydrocannabinol (THC) and its metabolites (Janeczek et al., 2018).

        Neurological Symptoms: Exposure to cannabis can lead to neurological symptoms such as mydriasis (dilated pupils), altered consciousness, and behavioral changes, which can persist and require hospitalization (Brutlag & Hommerding, 2018).

        Cardiovascular and Respiratory Effects:

        Systemic Effects: Cannabis extract and THC can cause hypotension (low blood pressure), bradycardia (slow heart rate), and respiratory depression in cats, indicating significant systemic impact (Graham & Li, 1973).

        Safety and Tolerability:

        Dosing Studies: Research on escalating doses of THC and CBD in cats showed that high doses can lead to adverse events such as lethargy, ataxia (loss of control of body movements), and hypothermia. These effects are dose-dependent but are generally transient and resolve without medical intervention (Kulpa et al., 2021).

        Veterinary Reports:

        Incidence and Treatment: Surveys of veterinarians in North America indicate that cannabis toxicosis in pets, including cats, is increasingly reported, especially with the rising accessibility of cannabis products. Most cases are treated with outpatient monitoring and supportive care (Amissah et al., 2021).

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