I will say that you don’t have to lie down and take it. Over the past few years I’ve been on a journey to restore and rejuvenate my body, and the results have been miraculous. I went from morbidly obese with metabolic syndrome, including uncontrolled high blood pressure, to literally the best physical condition of my life. 60 year old me could kick 30 year old me’s ass any day of the week. All of my health issues have been resolved, and all of my old man aches and pains have gone away. I did a deep dive on the state of the art of longevity science, which is reasonably summarized in Peter Attia’s book Outlive. (It’s a free audiobook on spotify premium.) I’ve basically optimized sleep, exercise, nutrition, supplements, and the use of prescription drugs, including the drug rapamycin. Rapamycin has extended lifespan of every organism it’s been tested in, including budding yeast, fruit flies, mice, rats, and non-human primates. While there are ethical and time considerations that make such placebo controlled lifespan studies in humans difficult, there is data to suggest that rapamycin has a similar therapeutic effect in humans. Joan Mannick’s 2014 study using Everolimus, a slightly tweaked analog of rapamycin, demonstrated that pulsed mTOR suppression in elderly humans greatly ameliorated immunosenescence, the decline in immune function during aging, and the ongoing trials of rapamycin with respect to ovarian aging have shown impressive effects. I’ve been on rapamycin for almost 3 years now, and while I can’t isolate its effects from my other interventions, I’m pretty much never sick and I’ve had significant grey hair reversal, which was unexpected. TLDR: there is a lot you can to mitigate the effects of aging and implement “graceful degradation” in your life.