I believe that the reason everyone is having an issue with your question - and your replies - is that you’re communicating poorly.

You seem to be inventing usages for words and terms that have well-established, widely understood meanings: “house trained” already means something unrelated to human behavior, but you seem to be using it in a way similar to “domesticated”. “Manic” is commonly associated with mental health conditions, so you being confused as to why that was mentioned doesn’t make sense when you were the one to mention mania:

Since when I experience protohuman traits such as Kill, Conquer and Reproduce. It doesn’t feel anything like what is explained or expected with Mania.

Also:

House trained (less calm (instead of more controlled)

I just can’t figure out what that is supposed to mean. Being civilized is less calm?

Regardless, to attempt to answer what I think you’re asking: these “protohuman traits” such as “Kill, Conquer, and Reproduce” were selected over millions of years of predatory competition. But once civilization became the dominant selection filter, survival was more contingent upon cooperation than domination and aggression.

Physiologically, our endocrine systems didn’t need to change, though - there’s been either not enough selection pressure or not enough time for there to be a noticeable difference in how we process various enzymes and hormones that we evolved to survive as hunter-gatherers. It simply hasn’t been necessary to our survival to “control” it.

Besides, it took millions of years and thousands of mutations across thousands of speciation events to develop that extremely complex system, and civilization has only been around for about 20,000 years, and - at most - two or three hominid species.