fullsquare
@fullsquare@awful.systems
- Comment on qt π 4 days ago:
I meant weaker per kg of body weight
- Comment on qt π 4 days ago:
Square-cube law means that as they get bigger they need to hunt less (lower rate of heat loss per kg of birb) and get less powerful compared to their size
- Comment on Behold and despair! 4 days ago:
some common friend spilled the tea in advance perhaps
- Comment on Why are so many after-shave lotion perfumed ? 6 days ago:
Tax reasons perhaps? In some countries ethanol with (certain kinds of) perfume mix can be taxed as denatured alcohol, otherwise some other kind of denaturant would be needed
- Comment on same shit every day, on god 1 week ago:
for ccgt it’s more like 2/3 for gas turbine, 1/3 for steam turbine split, even more uneven for diesel/steam because diesel exhaust is much colder
- Comment on same shit every day, on god 1 week ago:
and fuel cells
- Comment on Insulin 1 week ago:
as a citizen of a country whose government (-owned company) makes insulin, this reads weird to me
- Comment on Insulin 1 week ago:
good. generic biosimilars cost like 1/5 of the on-patent thing price
- Comment on Insulin 1 week ago:
fyi this fella has no training in chemistry or medicine and is just some random ass programmer with severe case of “saving the world from my homelab” symdrome
- Comment on Insulin 1 week ago:
I don’t think it’s a thing because even the same insulin analogue from different manufacturer can have different dosing
- Comment on Insulin 1 week ago:
90% of drug candidates fail in clinical trials
- Comment on Insulin 1 week ago:
couple of reddit threads suggest that this is something you can do, but you have to be evasive around american border guard later if you go in person
- Comment on Insulin 1 week ago:
i mean i don’t think about it as a separate budget line because if you don’t have that you get police raids and investigation instead of normal business, but yea. insulin is purified using HPLC, so at all times you get some of analytical data about fractions you just made, so some of QC, not all, but already something, already happens at this point
my point is that actual manufacturing costs will be low because biotech scalability logic is that you need to make yeast or something that makes peptide you like and then all you need to do is keep bioreactor alive and happy. lots of what is left is in purification
also it’s an injectable so it’s gonna be kept to some standards that non-injected drugs aren’t
- Comment on Insulin 1 week ago:
there are multiple short-acting and long-acting insulins because you can’t patent other people’s things, but now it’s all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you’re good to go
- Comment on Insulin 1 week ago:
I know not every state can or are willing to do this
this kind of thing scales well, i see no reason why after california has it set up, other states couldn’t get insulin from them, or chip in
- Comment on Insulin 1 week ago:
it might just be in glass vial and freezing broke it
- Comment on Insulin 1 week ago:
also european, but with some background: the problem is that there is natural (as in, unmodified) generic insulin available, it’s just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time, you don’t want to do that, you’d like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can’t reach it. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure
for another example, ozempic was not the first drug in its class, it’s also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it’s only two minutes (it gets released a bit slower than it is metabolized)
- Comment on Do you think there would eventually be technology to delete/replace memories (like the *Men In Black* device). How much do you fear such technology? (like misuse by governments/criminals) 2 weeks ago:
yes you can do it and it’s so easy it sometimes happens accidentally en.wikipedia.org/wiki/False_memory
- Comment on forbidden dots 3 weeks ago:
this is how 238Pu ceramic pellets for space probe generators look like, no fission required just alpha decay. If it was fission, it wouldn’t need to glow like this entire time because you can just turn it off
- Comment on Wi-Fi Extender, Long-Range, Suggestions? 4 weeks ago:
can you pull ethernet cable along power cables, wherever they are?
- Comment on Wi-Fi Extender, Long-Range, Suggestions? 4 weeks ago:
regular ethernet should work on this kind of distance, but it means digging
- Comment on Wi-Fi Extender, Long-Range, Suggestions? 4 weeks ago:
Mate do i have just the right thing for you, but it requires some soldering. It’s also probably cheapest solution working over longer range than you need
First you need two directional antennas. Use this lea.hamradio.si/~s53mv/wumca/cup.html the 13cm design specifically. They’re using hard to get semirigid coax but you can really just use common RG178 with braid tinned to make it stiff. Good way to get this would be getting a pack of u.fl-SMA pigtails, which you can also use for connection.
You also don’t need special aluminum housing like they do, cookie tin of the right size would be sufficient, or any other container of similar nature. If you can’t weatherproof it, putting it inside on windowsill is also fine
Then, plug TL-WN722N into it, or some other single-antenna thing, and you’re set. This one connects over USB and has removable RPSMA antenna, so you can connect it easily with correct cable (SMA plug - RPSMA plug)
to your new directional antenna. This thing works well over 200m distance, provided clear line of sight, and probably more than that
- Comment on China freezes chip chemistry to slash defects by 99 per cent 4 weeks ago:
it could be this www.nature.com/articles/s41467-025-63689-4
- Comment on New image-generating AIs are being used for fake expense reports 1 month ago:
in my country it used to be like this for 50 years, you get flat rate per day, counted up to fractions of day, separately for accomodation and food + everything else. you only have to keep transportation tickets
- Comment on New image-generating AIs are being used for fake expense reports 1 month ago:
behold, disruption
- Comment on Utter nonsense 1 month ago:
i don’t mean beta-oxidation, it’s just a series of separated normal reactions. i mean something like this: when first learning about ketones, you might learn about aldol condensation, which has enol as a nucleophile and another carbonyl as electrophile. at some other point you might learn about strecker reaction, which has iminium ion as electrophile and cyanide as nucleophile. but really, what you can do is mix and match, and you can pair enolizable ketone and iminium (mannich reaction) or carbonyl and cyanide (cyanohydrin formation) and then generalize, for example you don’t need strictly ketone for mannich, you can use any electron rich conjugated system like malonate or nitroalkane anion (henry reaction) or phenol or indole. to figure this out you need to study mechanisms. these last two are usually treated as variants of friedel-crafts reaction, but really categories like this are fake
and to get that right, you need to know how these reactive intermediates look like, how reactive they are, what influences their stability which means that ochem starts with discussion of carbocations, carboanions, radicals, their shapes and orbitals involved, hyperconjugation, solvent effects and the like. and then first reactions taught are sn1/sn2, because these showcase these fundamentals nicely, and from there, it’s about introduction of more compound classes
we only had synthons introduced during lecture at around 4th year, and only for ochem path, it’s not doing a lot at that point and imo would have much more impact right after ochem intro course
- Comment on Utter nonsense 1 month ago:
i always thought that the idea of synthons should be taught early on en.wikipedia.org/wiki/Synthon
- Comment on Utter nonsense 1 month ago:
i’d say it’s more important to learn mechanisms because this way you can notice these patterns of reactivity easier. at some point you’d only get new reactions that are really just pieces of other reactions you know put in a new way
- Comment on Utter nonsense 1 month ago:
there’s zero reason to make chart like this, it’s both barely comprehensible and touching surface level stuff only (where are palladium couplings for one)
- Comment on Mom they're fighting again 1 month ago:
