fullsquare
@fullsquare@awful.systems
- Comment on [deleted] 1 week ago:
- Comment on Firefox dev clarifies that AI features will be 'opt-in' and there will be a 'killswitch' to disable them 1 week ago:
no no no no it’s on by default so it’s opt-out, and switch for that isn’t even implemented yet
- Comment on Industrial Strength Shitpost 1 week ago:
at least he didn’t say he “fell on it” and it was totally an accident
- Comment on YOLO 1 week ago:
it can be bought in italy as a cleaning agent without going through entire process as for reagents purchase iirc
- Comment on Could gunpowder be chemically addictive for humans ? 2 weeks ago:
apparently ww1 era british soldiers figured out that cordite works like amyl but shittier (more specifically, nitroglycerin part) pdfs.semanticscholar.org/…/009c8713aadd8accbb03b2…
- Comment on Could gunpowder be chemically addictive for humans ? 2 weeks ago:
smokeless powder is, sort of en.wikipedia.org/wiki/Nitroglycerin#Industrial_ex…
- Comment on How does the private equity bubble compare to the AI bubble if at all? 2 weeks ago:
Or you could use different hardware, maybe from competition, because result isn’t worth electricity it used
- Comment on How does the private equity bubble compare to the AI bubble if at all? 2 weeks ago:
gpus as used for genai aren’t really suitable for normal loads like aerodynamic simulations, genai uses low precision data like fp8, fp4, blackwells and such are optimized for it so hard that you can’t really do anything else on this thing
- Comment on Sandy Loam 2 weeks ago:
nah. loam is, for example, 40% sand, 20% clay, 60 silt and it’s close to middle of that polygon
for example, draw a line from 50% sand to 50% clay,
- Comment on qt π 3 weeks ago:
I meant weaker per kg of body weight
- Comment on qt π 3 weeks ago:
Square-cube law means that as they get bigger they need to hunt less (lower rate of heat loss per kg of birb) and get less powerful compared to their size
- Comment on Behold and despair! 3 weeks ago:
some common friend spilled the tea in advance perhaps
- Comment on Why are so many after-shave lotion perfumed ? 3 weeks ago:
Tax reasons perhaps? In some countries ethanol with (certain kinds of) perfume mix can be taxed as denatured alcohol, otherwise some other kind of denaturant would be needed
- Comment on same shit every day, on god 3 weeks ago:
for ccgt it’s more like 2/3 for gas turbine, 1/3 for steam turbine split, even more uneven for diesel/steam because diesel exhaust is much colder
- Comment on same shit every day, on god 3 weeks ago:
and fuel cells
- Comment on Insulin 4 weeks ago:
as a citizen of a country whose government (-owned company) makes insulin, this reads weird to me
- Comment on Insulin 4 weeks ago:
good. generic biosimilars cost like 1/5 of the on-patent thing price
- Comment on Insulin 4 weeks ago:
fyi this fella has no training in chemistry or medicine and is just some random ass programmer with severe case of “saving the world from my homelab” symdrome
- Comment on Insulin 4 weeks ago:
I don’t think it’s a thing because even the same insulin analogue from different manufacturer can have different dosing
- Comment on Insulin 4 weeks ago:
90% of drug candidates fail in clinical trials
- Comment on Insulin 4 weeks ago:
couple of reddit threads suggest that this is something you can do, but you have to be evasive around american border guard later if you go in person
- Comment on Insulin 4 weeks ago:
i mean i don’t think about it as a separate budget line because if you don’t have that you get police raids and investigation instead of normal business, but yea. insulin is purified using HPLC, so at all times you get some of analytical data about fractions you just made, so some of QC, not all, but already something, already happens at this point
my point is that actual manufacturing costs will be low because biotech scalability logic is that you need to make yeast or something that makes peptide you like and then all you need to do is keep bioreactor alive and happy. lots of what is left is in purification
also it’s an injectable so it’s gonna be kept to some standards that non-injected drugs aren’t
- Comment on Insulin 4 weeks ago:
there are multiple short-acting and long-acting insulins because you can’t patent other people’s things, but now it’s all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you’re good to go
- Comment on Insulin 4 weeks ago:
I know not every state can or are willing to do this
this kind of thing scales well, i see no reason why after california has it set up, other states couldn’t get insulin from them, or chip in
- Comment on Insulin 4 weeks ago:
it might just be in glass vial and freezing broke it
- Comment on Insulin 4 weeks ago:
also european, but with some background: the problem is that there is natural (as in, unmodified) generic insulin available, it’s just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time, you don’t want to do that, you’d like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can’t reach it. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure
for another example, ozempic was not the first drug in its class, it’s also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it’s only two minutes (it gets released a bit slower than it is metabolized)
- Comment on Do you think there would eventually be technology to delete/replace memories (like the *Men In Black* device). How much do you fear such technology? (like misuse by governments/criminals) 5 weeks ago:
yes you can do it and it’s so easy it sometimes happens accidentally en.wikipedia.org/wiki/False_memory
- Comment on forbidden dots 1 month ago:
this is how 238Pu ceramic pellets for space probe generators look like, no fission required just alpha decay. If it was fission, it wouldn’t need to glow like this entire time because you can just turn it off
- Comment on Wi-Fi Extender, Long-Range, Suggestions? 1 month ago:
can you pull ethernet cable along power cables, wherever they are?
- Comment on Wi-Fi Extender, Long-Range, Suggestions? 1 month ago:
regular ethernet should work on this kind of distance, but it means digging