Support from local and state governments does make a difference though. While federal agencies can still enforce these laws, local/state agencies could look the other way. Cannabis is still federally illegal, but some states have basically said “no thanks, we’re good as long as you stick to our rules on it.”

It comes down to how much state governments want to go to bat for their constituencies and how much the federal government wants to press the issue. All else being equal, I’d rather be in a state that stands up for my rights than one that doesn’t.