Sorry to hear things are rough for you. I hope whatever is causing them improves!

Mine is an odd choice, or maybe not, but its the first thing that came to mind: Night in The Woods

It’s about a girl that comes home from college to her old dying town. I know that doesn’t sound terribly uplifting, and there’s some downer stories mixed in there, but overall I found it a very heartfelt and uplifting game, because the main character’s friends are the most wonderful bunch of people, and you hang out with them and go on little adventures throughout. It’s got a cool creepy mystery story going on, but the game is mostly about deep friendship, family, and overcoming struggles with their help, and I found that very uplifting and worthwhile.