Know Your Meme’s page on Loss.

Basically, a 2000s webcomic about gamer culture devoted a comic (titled Loss) to the writer’s partner who had a miscarriage. It’s four wordless panels, and the characters in each panel take up roughly the positions of the rectangles in the OP.

Tonally, it was the complete opposite of what the webcomic normally covered, and it really shocked its readers who, being an internet community, responded with irony and parody, and now there are a ton of Loss references out there.