Comment on not even once

TranscendentalEmpire@lemmy.today ⁨6⁩ ⁨days⁩ ago

• Hackworth@piefed.ca ⁨6⁩ ⁨days⁩ ago

  Are there families without some history of mental illness?

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• chocrates@piefed.world ⁨6⁩ ⁨days⁩ ago

  Is salvia a psychedelic?

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  • TranscendentalEmpire@lemmy.today ⁨6⁩ ⁨days⁩ ago

    Yeah, but it’s a weird one. Unlike most other psychedelics it’s not an alkaloid and it doesn’t interact with your serotonin receptors. Instead it has a high affinity for the k-opioid receptor and disrupts the release of dopamine in certain parts of your brain.

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  • WhiteOakBayou@lemmy.world ⁨6⁩ ⁨days⁩ ago

    It is as psychedelic as dmt it just isn’t pleasurable at all. On breakthrough doses your awareness is altered but you aren’t intoxicated like on the classical psychedelics. It is a hard one to explain but you are disassociated in the regular sense, the ego death is real but not in the numinous way of serotonergic drugs. I was once a square wheel on a truck. And I lived a whole life that way. I remember way more of what happens in my salvia breakthroughs than in my dmt ones. I think the dmt ones would be just as unpleasant though if dmt wasn’t itself pleasurable.

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  • Hackworth@piefed.ca ⁨6⁩ ⁨days⁩ ago

    It’s in a category of its own. It’s pretty interesting.

    https://en.wikipedia.org/wiki/Salvinorin_A#Pharmaceutical_action

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    • MonaySimpson@lemmy.ml ⁨6⁩ ⁨days⁩ ago

      Basically a dissociative right?

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