Comment on Protein folding is not solved yet

• sharkfucker420@lemmy.ml ⁨3⁩ ⁨weeks⁩ ago

  A reliable way to simulate any kind of protein fold. As long as you have a method you could hypothetically “solve” the issue

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  • SaveTheTuaHawk@lemmy.ca ⁨3⁩ ⁨weeks⁩ ago

    You dont solve anything. You generate models. That’s it. Without experimental validation they are just cartoons.

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    • sharkfucker420@lemmy.ml ⁨3⁩ ⁨weeks⁩ ago

      Then why has modelling been so focused on?

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      • Hazel@piefed.blahaj.zone ⁨3⁩ ⁨weeks⁩ ago

        Because the models become a database you can search for certain characteristics.

        (This is a guess I consider reasonable.)

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      • Huegoe@fedinsfw.app ⁨3⁩ ⁨weeks⁩ ago

        Its somewhat complex. Protein structures are usually solved with x-ray crystallography. You get a 2-dimensional diffraction pattern. There are different methods to “solve” tghe diffraction pattern and get the Protein structure. Most are a lot of work, including biochemical lab work. But if you have a model it is relatively easy. The modern computer generated models have revolutionized protein x-ray crystallography.

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• SaveTheTuaHawk@lemmy.ca ⁨3⁩ ⁨weeks⁩ ago

  There actually aren’t. However, some of the most interesting proteins have no structure at all.

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  • ranzispa@mander.xyz ⁨3⁩ ⁨weeks⁩ ago

    The interesting part would be to a reliable and computationally accessible way to handle disordered proteins. Seeing how they can move could be quite revolutionary.

    I had to work on some disordered proteins and you’re pretty much just guessing, plausibly you’re better off going to a casino blindfolded and play blackjack.

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