Picked this game up a couple of days ago.

Here’s some tips I’ve been using myself:

• Duplicants

Only pick duplicants when you actually need them. The best ones have a single stat. At first, you’ll need a digger, scientist, and constructor. You’ll basically want one for each job, depending on your priorities.

• Getting things done

Use priority tab. Have only one dedicated cook, the rest is based on skills.

Use scheduling tab. Duplicate existing schedule and shift it a bit. Make it so only half of your duplicates sleep or use the bathroom at a time.

• Power/Oxygen

Connect a wheel to 2 batteries, connect them to a single diffuser. This will be enough oxygen for a long while

• Food

Want food? Go digging. Want more food? Plant Mealwood on dedicated farming tiles. It doesn’t require much at all to grow.

• Germs

Make a dedicated bathroom. 4 toilets, 4 sinks. Make sure it fits one of the dedicated room sinks change the arrow so that duplicant only wash hands on their way out.

• Water and pollution

Make 2 reservoirs. One for clean water, one for polluted in an enclosed environment. Clean polluted water with Water Sieve and polluted air from the reservoir with Deodoriser.

There’s also more advanced stuff like making chlorine rooms or liquid airlocks, but I haven’t gotten myself there myself yet.