Boiling and changing the water removes the psychoactive compounds as well as the ones that keep you on the toilet all day if you’ve done it correctly (both are water-soluble). At that point it’s just a culinary mushroom.

People who are “detoxifying” it to use as a drug bake it at a low temperature which does a poor job of removing any of the toxic or psychoactive compounds so they get a bad high and end up on the toilet half a day (seriously, just order some cube spores or something if IDing good actives is too hard).