Comment on Beer is for GIRLS
Atelopus-zeteki@fedia.io 2 days ago
Flavonoids as Phytoestrogenic Components of Hops and Beer
https://pmc.ncbi.nlm.nih.gov/articles/PMC7570471/
The Effects of the Hops Phytoestrogen in Beer on Breast Cancer Risk
https://nutritionfacts.org/blog/the-effects-of-the-hops-phytoestrogen-in-beer-on-breast-cancer-risk/
tl/dr - beer because of the ethanol, and 8-PN from hops, which is a selective estrogen receptor alpha promoter is proliferative on breast cells thus increasing breast cancer risk. And at the same time lowers risk for osteoporosis.
Tho' some sources (https://www.greenskybio.com/hops_extract/37420.html) say 8-PN exists at extremely low concentrations in beer as it is served.
faythofdragons@slrpnk.net 2 days ago
I thought phytoestrogens didn’t affect humans?
rainwall@piefed.social 2 days ago
They dont effect your mammalian estrogen levels, but they do have an effect on you like every chemical you ingest.
faythofdragons@slrpnk.net 2 days ago
The second link says it affects estrogen levels though, which is why I’m confused.
Is this new research?
Atelopus-zeteki@fedia.io 2 days ago
Right, so all of this indicates that phytoestrogens indeed do have effects on mice and human estrogen related physiology. The effects can be a little puzzling, though. As I understand it, there are two types of estrogen receptors, Alpha and Beta. And there are many phytoestrogens as well as estrogenic chemicals that we are exposed to, with the one's in beer binding to Estrogen Receptor Alpha, which signals breast cells and breast cancer cells to proliferate. The binding affinity of the phytoestrogens is weaker than that of the endogenous estrogen. None the less when a given phytoestrogen is bound to a given receptor it gives a slightly weaker estrogen-like signal, and simultaneously prevents the binding of the endogenous estrogen (can't fit two keys into a single lock at the same time), which has a stronger affinty, and thus stronger effect when it is bound to the receptor. So in an individual with lots of estrogen, the phytoestrogen may lower the estrogenic signal, and in someone with less estrogen it may augment the estrogenic signal in the body. Does that make sense? Do you have questions?