I am going to hypothesize here: depends on how long rat’s in the tube.

I’m imagining a scenario where a vet has to X-ray a pet rat. Rat goes in the tube for 5 minutes while images are taken and then Rat can come back out of the tube. Rat’s probably going to be okay. A treat may be in order.

If he had to stay in there for a month, I don’t think he’ll ever be a normal rat again.