Comment on Would eating raw human brains make you high?
Nurse_Robot@lemmy.world 8 months agoI don’t think that’s correct.
Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation
medgremlin@lemmy.sdf.org 8 months ago
The lower colon really only transports water and a couple of vitamins released by gut biota, so if they’re getting far enough in that more complex molecules would be taken up, that would probably be up into the hepatic portal system.
The reason “boofing” works for alcohol is because ethanol is actually a rather small molecule, all things considered.