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It would still go through the liver for metabolism. The only thing “boofing” effectively does is skip the stomach part of the digestive process. To take up anything from the digestive tract, it gets transported through the intestinal lumen and into the mesenteric and hepatic portal system. The liver filters everything that gets into the blood from the gut before it goes into the inferior vena cava and into the rest of the circulatory system.

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Nurse_Robot@lemmy.world ⁨1⁩ ⁨year⁩ ago
I don’t think that’s correct.

Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation

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- medgremlin@lemmy.sdf.org ⁨1⁩ ⁨year⁩ ago
  The lower colon really only transports water and a couple of vitamins released by gut biota, so if they’re getting far enough in that more complex molecules would be taken up, that would probably be up into the hepatic portal system.
  
  The reason “boofing” works for alcohol is because ethanol is actually a rather small molecule, all things considered.
  
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