Different systems. So probably synergistic effect but I’m not an expert.
Since Endorphins and Serotonin are two completely different chemicals which give the biggest "High"? And does the release of some of one of them overcompensate for the other? How come?
Submitted 7 hours ago by Patnou@lemmy.world to [deleted]
DrBob@lemmy.ca 6 hours ago
This is related to what I used to study. I’d say the difficulty with the question lays with how we interpret “biggest high”. Stimulation of those systems produces a qualitatively different user experience, and even more so depending on the dose, mechanism, and selectivity of the agonist. So serotonergic activation can produce experiences that range from relaxation to full blown psychedelic experiences. Activation of the opioid system can produce warm comfort to catatonia.