Using one of those FTDI kenwood adapter programming cables. My gut feeling is no. It would be nice for things like sending/receiving SSTV images.

I am able to transmit if I use a double ended male 3.5 mm cable in the microphone hole of the radio and the headphones hole in my computer, but I have to hold down the PTT button. Also I have to turn the volume on my computer down a lot or else it is distorted. I suspect this has something to do with “line out” versus “headphones” voltage levels (I recall seeing some YouTube video discuss this).