Gru (Steve Carell) and Lucy (Kristen Wiig) and their girls — Margo (Miranda Cosgrove), Edith (Dana Gaier) and Agnes (Madison Polan) — welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru faces a new nemesis in Maxime Le Mal (Will Ferrell) and his femme fatale girlfriend Valentina (Sofía Vergara), and the family is forced to go on the run.