It’s about technological advancement and its augmentation of the human condition (think social media, phones, and the internet). There are people who resist these changes, often mislabelled as ‘luddites’ (the Luddites of the 19th century specifically opposed automation for its threat to jobs, but were reprehensive of all technology as a part of that).

This meme is just taking those who berate Luddites to their ultimate conclusion, which is a hive mind where all personal autonomy is lost, and it could be argued they cease to exist as a distinct individual. The flesh part of it is merely a means of making it more grotesque.