Unfortunately there are way too many variables just to answer that definitively.

If you put a thousand Watt resistive heater in a room 1,000 watts will generate 1000 watts worth of heat give or take. But if you use a heat pump, 1000 watts of power can be used to move 3,500 Watts worth of heat outside to in. Speaking from a theoretical power concept.

If you’re heating your entire house to 20 or 30° above ambient, you’ll have losses on the roof in every wall, If you’re just eating one room all you have are the losses of that room so insulation becomes a weird thing to calculate.

You can’t just let your pipes freeze if you’re a freezing zone, but generally unless you’re central is super efficient, maintaining a comfortable temperature in one room is more cost-effective, heating one room should cost somewhat less than try to heat the whole house no matter what method you’re using.