Speaking from experience here. I’ve done this on over a dozen different computers with zero issues over a three month span. It was part of a proposal for transitioning our company computers to Windows 11 while cutting out the junk. None of them had any problems running without Xbox services, Cortana, bloatware games, activity tracking, etc.

We ended up using Microsoft Intune for restricting Windows 10/11 to our standards. But that’s not really available for consumers and debloaters are safe to use instead.