Forget Wine for GW2. If you are lazy just install Steam & add GW2 as an external game to run with Proton.

If you are not lazy, then install Bottles, give it permissions to the correct GW2 folder with Flatseal & then download the soda 7 runner in Bottles settings. After all this make a default gaming bottle, then change the runner in that bottle to soda 7, enable latency flex to lower the latency at the cost of slightly lower average fps & play.