Comment on C'mon
peopleproblems@lemmy.world 4 months agoI don’t think Adderall affects serotonin receptors, just dopamine and some norepinephrine.
However, that tiny ass dose of Zoloft could be a huge ass dose if your body doesn’t break it down.
catbum@lemmy.world 4 months ago
I had definitely thought that as well! But then I googled it and found there can be “major interactions” between Adderall and Zoloft, and that Adderall can actually affect serotonin (not sure if it promotes more serotonin or inhibits reuptake). It must be some kind of compounding effect?
But great point on the Zoloft! It seems it was definitely an OD factor, especially if there is more serotonin floating up there “naturally” and the re-uptake inhibition becomes way more effective. 😬
(I’m still actually dealing with tapering off Zoloft, but oh my gods I am so much less physically anxious already.)
Waveform@lemmy.world 4 months ago
I just did a quick search, and found this:
www.ncbi.nlm.nih.gov/pmc/articles/PMC4309786/
While it doesn’t specifically name Zoloft (Sertraline), it seems to boil down to how the body uses its own enzymes needed to metabolize drugs. You can end up getting pronounced effects from both drugs because they use/affect the same enzymes.