It’s different because these are now metallic compounds, which can become magnetically charged and may be able to affect the magnetosphere.

The magnetosphere is basically the ball of magnetic force around the earth that insulated us from solar winds.

Solar winds can destroy planetary atmospheres, when the planet isn’t otherwise protected.

The hole in the ozone layer was also a problem, but it’s more because the ozone layer protects us from a lot of ultraviolet light. The hole (which was not exactly a hole, but that works better for marketing) would have caused a bunch of cancer and exposed us to higher levels of toxic ozone on the ground, which are both big problems, but not for all life on earth