I don’t see any ethical issue with it, just an artistic one. To me, it’s akin to altering dialog or story in a film or book. IMO, for a first play-through, you should want to experience what the game’s creator wanted you to experience, even if it’s uncomfortable. After that, mod and cheat to your heart’s content.

To me, the ability for a game to simulate situations which force you to confront emotions you would otherwise avoid or never have is what makes games an art form. The first time you lose a pawn in Rimworld, getting frustrated at a boss in Elden Ring, your favorite Pokemon evolving, meeting a new neighbor in Animal Crossing, falling in lava in minecraft; all of these moments could be cheapened or circumvented entirely by cheating, and IMO the only person you’ve cheated is yourself out of a unique experience. I call it Emotional Min/Maxing, and I consider it a form of optimizing the fun out of a game.