Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.

That kind of information is important in an emergency medicine situation, it’s not worth pretending that it’s not the case.