The disability bit is hard. There are medical exclusions for going into Canada. I’m on that road right now and I have a heart issue which, for me, equals disabled. My best advice is talk to an immigration specialist - but be sure to check that they are legit and have the right certifications.

Otherwise,like other people are saying, it’s a lot about skills. If your brother is amenable to going to a school in Canada, that’s also an easier way. It’s not a guarantee, but a student visa will last a bit and then having that already Canadian training, it’s easier to be hired by those companies.

Good luck