That actually is really interesting, thanks for sharing that article. It is of note that this study is in mice, so who knows if it translates to humans in the same way, but the results are encouraging. Without more info it is hard to say if centenarians got to that age because of the nicotine or if it was some other lifestyle choice/genetic trait or even dumb luck. Im more hesitant to say it’s definitely the nicotine based off of these results.