One setting I recommend, though maybe not for the first time, is turning the infection timer, or whatever it’s called, to 0. In vanilla default settings you may be infected when bitten, but not always. There’s no cure, so you’re just waiting to find out if you’re infected, and it takes a while. At first it just looks like it could be a normal infected wound, but things keep getting worse. The standard “solution” at this point is to drink some bleach to die and start over. I prefer to skip all the waiting and have it instantly kill me if I get infected.