Depends on who you ask. The sorts of people who call her that are bigoted rightwingers, most famously Jerry Falwell. This animosity dates back to the 90s when she had a sitcom. She came out and the right wing lost its shit about it, and there’s still hate for her today. No surprise it got upvotes on reddit.

Independently of that, she’s evidently just plain mean to anyone she can get away with mistreating.