Highly dependant on the game and the content.

NieR Automata has you get 5 endings and see the credits roll at least twice in order to actually get all of the story, and the content is actually very different. Like the credits rolling isnt treated as the end of the game, just a way to break up the pacing.

But if the game is highly repetitive, extremely linear, and exactly the same on subsequent playthroughs? Nah.