Do you guys turn your graphics settings to lowest

Pretty much, yeah, lows whenever possible and mediums whenever lows are way too low (i.e. shadows, where low usually means pre-baked only, while medium does dynamic, yet blurry, shadows), and all post-processing disabled. Highs and ultras never provide any tangible difference during gameplay and their use is seemingly mostly limited to benchmarks.

and most modern anti-aliasing too

TAA can eat a dick. I’d take staircases over ghost edges and flickering shadows any day every day.