I’m not gonna critique it based on efficiency and min-maxing as that’s something I couldn’t care less about. Design wise however, I like it. It’s has some more organic and interesting shapes than a basic “American city” that’s so easy to default to. Split between suburbs and the more urban centre is a nice touch (tough I would try to add some transition in the empty space between the two to make it look more natural).

You have a clear separation between residential and industrial areas which will prevent issues with health and happiness (as long as you keep it in check). You also remembered to dump the sewers downriver which is good.

I’m sure some CS pro could give you a bunch of pointers but it looks like a good start to me. Are you planning to share your progress in the future? I’d actually like to see what you’ll do with it.