You’d be lacking shortcuts obviously, and very rarely (mostly when you ask for it) you might be prompted to input a name for something, but almost everything else has mouse controls.

Now that I think about it, there are two keys that might be a bit inconvenient not to have, space-bar for emergency pauses (there’s a screen button but it’s harder to hit in a bind) and shift that let you queue an order instead of replacing the current one.