In the first region in the midst of the first small village two neighbors are arguing. They are not giving a quest, they just talk to each other and listening gives such an insight in how war can turn people against each other that have been living peacfully and been friends for years.

Do the side quests and take your time with the dialogue. Some of these stories are impactful, mostly sad and worth your time. If you are told that you should talk to people to find out more about your contract, do it. Some of these quests can be done with only talking to one person but you want to get the information from everyone and especially their side of the story.

Do not look up the outcome of decisions. Make your decisions and live with them at least at your first playthrough. Most decisions have impact and seeing the outcome unfold makes this game special and yes often there is no “good choice” - that’s war for you.

Last: Buy every Gwent card you can get your hands on and play with everyone you can. If you can’t win just come back later with better cards and obliterate them - it will feel goooood!

The DLC’s are a must.

Try out difficulty settings - there is a sweet spot for most people somewhere but what it will be for you no one can know, but it would be a shame if you play through the game not having found the difficulty that fits you best because you “always play on <insert difficulty>”.

Have fun, I wish I could play this game for the first time again.