Comment on How does DNA decide the shape of the body?

goddard_guryon@sopuli.xyz ⁨7⁩ ⁨months⁩ ago

Like you said, there’s a metric ton of steps involved in the overall process, and our understanding of each of these ‘levels’ of organization varies quite a bit. Closest to my personal expertise is the sub-cellular and cellular level, for which I would refer you books or papers in developmental biology, developmental genetics, and epigenetics. I can give you a couple bloopers to get you excited though:

When it comes to deciding where different organs will form (again, from a sub-cellular level), it essentially starts from a gradient of certain proteins/chemicals inside the zygotic cell. This gradient then determines the level of activation of other proteins, each level then leading to different biochemical cascades which, once more cells have formed from the zygote, determine which organ systems will come from them. A, more or less, similar process occurs to determine the shape of organs. As a simple example, when some animals with regenerative capabilities (like axolotls) lose a limb, they are able to regrow the limb to the exact same length as before. Turns out, each cell on the periphery of their limb has a certain concentration of receptor proteins on its surface, which acts as a molecular ‘signature’ of that cell’s position in the limb. These signatures provide information on how far to grow the limb for regeneration, and some chemicals, lile retinol, can even override these signatures and fool the organism’s body into regrowing the limb from scratch on top of the place of regeneration.

I hope these examples give you a sufficient introduction of the mechanisms involved. There’s obviously a lot more involved, so I would again highly recommend textbooks and research papers if you’re interested.

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