If it’s all stuff he really does in real life, how could he sue over it? If it’s factual, you can’t sue. Well you could but you’d lose because South Parks lawyers would say “show me what we said that wasn’t true”

If it’s its fictional and they clearly state at the beginning of the episode that it’s fictional and you should not assume it’s true, it’s going to be really hard to convince a judge that they were trying to trick people into thinking something was true.