On my first playthrough of a game, I almost never cheat. Get the intended experience etc.

If I play it again, I almost always look for mods, maps and cheats to add or remove features and allow me to set my own difficulty. Often I want to do a hard mode but without one or two particularly tedious features.

Sometimes I will make a game super easy because I like its core loop but I am not in the mood for a challenge. Or if there’s a achievement that will take ages to get and I am sure I could do it in time but am not willing to expend the effort.